Results 111 to 120 of about 975,123 (280)
On the developable surfaces. [IV.] [PDF]
Časopis pro pěstování matematiky a fysiky, 1880 openaire +4 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FREE-FORM TOOLS DESIGN AND FABRICATION FOR FLANK SUPER ABRASIVE MACHINING (FSAM) NON DEVELOPABLE SURFACES [PDF]
, 2019 Manufacturing improvements are becoming a real need in industry. In order to satisfy these industrial requirements, they should be targeted in two different directions: new manufacturing processes and surface optimization through algorithms. On the one
Fernández-Lucio, P. +6 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
About Measuring the Stress Intensity Factor of Cracks in Curved, Brittle Shells
Fracture and Structural IntegrityMost techniques of measuring the stress intensity factor (SIF) in the cracking process assume a crack in a planar medium. Currently, there is no effective approach for curved brittle shells, particularly for non-developable cases, i.e., shapes with non ...
Andras A. Sipos, Siwen Cao
doaj +3 more sources
Optimisation of a developable surface model passing through a helical curve with variable pitch
Machinery & EnergeticsInsufficient consideration of the developable helical surfaces in engineering practice complicates their manufacture and design, especially for variable pitch surfaces.
A. Nesvidomin +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source