Results 111 to 120 of about 1,441 (285)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A Survey of Developable Surfaces: From Shape Modeling to Manufacturing
, 2023 Developable surfaces are commonly observed in various applications such as architecture, product design, manufacturing, and mechanical materials, as well as in the development of tangible interaction and deformable robots, with the characteristics of ...
Shi, Yang, Yuan, Chao, Cao, Nan
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ON DEVELOPABLE SURFACES. AN OVERVIEW
Journal of Industrial Design and Engineering Graphics, 2017 The ruled surfaces, generated by a straight line moving in space in accordance with a certain law, exibit special properties that confer them a wide range of practical applications.
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Note on Parametric Surfaces in Minkowski 3-Space
The Scientific World Journal, 2014 With the help of the Frenet frame of a given pseudo null curve, a family of parametric surfaces is expressed as a linear combination of this frame. The necessary and sufficient conditions are examined for that curve to be an isoparametric and asymptotic ...
Esra Betul Koc Ozturk
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
FREE-FORM TOOLS DESIGN AND FABRICATION FOR FLANK SUPER ABRASIVE MACHINING (FSAM) NON DEVELOPABLE SURFACES [PDF]
, 2019 Manufacturing improvements are becoming a real need in industry. In order to satisfy these industrial requirements, they should be targeted in two different directions: new manufacturing processes and surface optimization through algorithms. On the one
Fernández-Lucio, P. +6 more
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