Results 101 to 110 of about 1,441 (285)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Singularities of Developable Surfaces [PDF]

, 1999
In this survey article we explain the recent results on the singu­larities appearing in the tangent developables of space curves via the projective duality.
Ishikawa, G., Go-O Ishikawa
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Building with developable surfaces

, 2023
Une feuille de papier, une tôle d’acier, un panneau de contreplaqué ou encore une plaque de verre prennent naturellement la forme d’une surface développable lorsqu’ils se déforment.
Leduc, Nicolas
core  

INFINITESIMAL ISOMETRIES ON DEVELOPABLE SURFACES AND ASYMPTOTIC THEORIES FOR THIN DEVELOPABLE SHELLS [PDF]

, 2012
We perform a detailed analysis of first order Sobolev-regular infinitesimal isometries on developable surfaces without affine regions. We prove that given enough regularity of the surface, any first order infinitesimal isometry can be matched to an ...
Peter Hornung, Marta Lewicka, Mohammad Reza Pakzad, Pakzad, M R, Hornung, Peter, Lewicka, M   +5 more
core   +1 more source

Secant Cylinders Are Evil—A Case Study on the Standard Lines of the Universal Transverse Mercator and Universal Polar Stereographic Projections

ISPRS International Journal of Geo-Information
The literature usually calls downscaled versions of basic conformal map projections “secant”, referring to conceptual developable map surfaces that intersect the reference frame.
Krisztián Kerkovits
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Static analysis of shells with developable middle surfaces

, 2020
This review article is devoted to an analysis of the literature on the stress-strain state of shells with developable middle surfaces. Wide choices of design methods for the developable surfaces provide not only the necessary shapes and special ...
Krivoshapko S.N.
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source