Results 81 to 90 of about 975,123 (280)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Determination and (re)parametrization of rational developable surfaces [PDF]
, 2015 The developable surface is an important surface in computer aided design, geometric modeling and industrial manufactory. It is often given in the standard parametric form, but it can also be in the implicit form which is commonly used in algebraic ...
Pérez Díaz, Sonia +3 more
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Tangent developable surfaces elements in thinwalled structures [PDF]
, 2017 This report demonstrates the capabilities of an advanced research area of the applied mathematics, i.e., computational geometry to be applied for shaping dimensional structures.
Berestova, Svetlana A. +2 more
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The Ruled Surfaces According to Bishop Frame in Minkowski 3-Space
Abstract and Applied Analysis, 2013 We investigate the ruled surfaces generated by a straight line in Bishop frame moving along a spacelike curve in Minkowski 3-space. We obtain the distribution parameters, mean curvatures.
Nural Yüksel
doaj +1 more source
Generating and flattening developable surfaces
, 1994 In this paper, methods for generating and flattening developable surfaces by means of two given directrix curves have been investigated. By finding the two end points of every generatrix, a developable surface may be formed.
Tan, ST, Gan, MC, Chan, KW
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Bridging the gap between rectifying developables and tangent developables: a family of developable surfaces associated with a space curve. [PDF]
Proc Math Phys Eng Sci, 2021 Seguin B, Chen YC, Fried E.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source