Results 71 to 80 of about 975,123 (280)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Survey of Developable Surfaces: From Shape Modeling to Manufacturing [PDF]
, 2023 Developable surfaces are commonly observed in various applications such as architecture, product design, manufacturing, and mechanical materials, as well as in the development of tangible interaction and deformable robots, with the characteristics of ...
Shi, Yang, Yuan, Chao, Cao, Nan
core +1 more source
Non-developable ruled surfaces [PDF]
, 2019 The bachelor thesis deals with non-developable ruled surfaces, their theroretical description and procedures of creating physical models for educational purposes.
Duspivová, Jiřina
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Developable Surfaces from Arbitrary Sketched Boundaries [PDF]
, 2007 International audienceDevelopable surfaces are surfaces that can be unfolded into the plane with no distortion. Although ubiquitous in our everyday surroundings, modeling them using existing tools requires significant geometric expertise and time.
Wither, Jamie +4 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2005 Recurring to some excellent geometric and algebraic properties of Poisson curves, we present an algorithm that generates a developable Poisson surface through a Poisson curve of arbitrary degree.
Xingwang Zhang, Guojin Wang
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Singularities for One-Parameter Developable Surfaces of Curves
, 2019 Developable surfaces, which are important objects of study, have attracted a lot of attention from many mathematicians. In this paper, we study the geometric properties of one-parameter developable surfaces associated with regular curves.
Yongqiao Wang, Qiming Zhao, Donghe Pei
core +1 more source