Results 11 to 20 of about 1,740,435 (334)

Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion

BMC Neuroscience, 2023
Background Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex is hypothesised to be critical ...
Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price, Thomas Pratt   +11 more
doaj   +1 more source

Ex-utero third trimester developmental changes in functional brain network organization in infants born very and extremely preterm

Frontiers in Neuroscience, 2023
IntroductionThe latter half of gestation is a period of rapid brain development, including the formation of fundamental functional brain network architecture.
Kevin M. Cook, Josepheen De Asis-Cruz, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Adré J. du Plessis, Catherine Limperopoulos   +7 more
doaj   +1 more source

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

Journal of Neuroinflammation, 2022
Encephalopathy of prematurity (EoP) affects approximately 30% of infants born
Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton, Helen B. Stolp   +16 more
doaj   +1 more source

Characterisation of ASD traits among a cohort of children with isolated fetal ventriculomegaly

Nature Communications, 2023
Isolated fetal ventriculomegaly is the most common antenatally-diagnosed brain abnormality. Here, the authors show that isolated fetal ventriculomegaly is associated with autism spectrum disorder traits.
Vanessa Kyriakopoulou, Alice Davidson, Andrew Chew, Nidhi Gupta, Tomoki Arichi, Chiara Nosarti, Mary A. Rutherford   +6 more
doaj   +1 more source

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]

, 2015
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan, Li, Jinhui, Li, Xihong, Mu, Dezhi, Qu, Yi, Tang, Jun, Wu, Jinlin, Xiong, Tao, Zhang, Li   +8 more
core   +2 more sources

Cerebral organoids as tools to identify the developmental roots of autism

Molecular Autism, 2020
Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constraints.
Wai Kit Chan, Rosie Griffiths, David J. Price, John O. Mason   +3 more
doaj   +1 more source

Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Infants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated with impaired brain growth.
Daniel Cromb, Alexandra F. Bonthrone, Alessandra Maggioni, Paul Cawley, Ralica Dimitrova, Christopher J. Kelly, Lucilio Cordero‐Grande, Olivia Carney, Alexia Egloff, Emer Hughes, Joseph V. Hajnal, John Simpson, Kuberan Pushparajah, Mary A. Rutherford, A. David Edwards, Jonathan O'Muircheartaigh, Serena J. Counsell   +16 more
doaj   +1 more source

The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain [PDF]

, 2012
The developing brain of Drosophila has become a useful model for studying the molecular genetic mechanisms that give rise to the complex neuronal arrays that characterize higher brains in other animals including mammals.
Bello, B. C., Kuert, P. A., Reichert, H.
core   +3 more sources

Ligand and Carbohydrate Engagement (LACE) Assay and Fluorescence Quantification on Murine Neural Tissue

Bio-Protocol, 2021
The interaction between cell surface heparan sulphate and diffusible ligands such as FGFs is of vital importance for downstream signaling, however, there are few techniques that can be used to investigate this binding event.
James Clegg, Thomas Pratt
doaj   +1 more source

Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project

Translational Psychiatry, 2023
Increasing lines of evidence suggest deviations from the normal early developmental trajectory could give rise to the onset of schizophrenia during adolescence and young adulthood, but few studies have investigated brain imaging changes associated with ...
Hai Le, Konstantina Dimitrakopoulou, Hamel Patel, Charles Curtis, Lucilio Cordero-Grande, A. David Edwards, Joseph Hajnal, Jacques-Donald Tournier, Maria Deprez, Harriet Cullen   +9 more
doaj   +1 more source