Results 71 to 80 of about 5,553,659 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Skilled migration: the perspective of developing countries [PDF]

This chapter focuses on the effects of skilled migration on developing countries. We first present new evidence on the magnitude of the "brain drain" at the international level. Using a stylized model of education investment in a context of migration, we
Hillel Rapoport, Frederic Docquier
core  

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide. [PDF]

, 2018
Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs.
조윤성, 김세훈, 강석구
core   +1 more source

On the need for bundle-specific microstructure kernels in diffusion MRI

NeuroImage, 2020
Probing microstructure with diffusion magnetic resonance imaging (dMRI) on a scale orders of magnitude below the imaging resolution relies on biophysical modelling of the signal response in the tissue.
Daan Christiaens, Jelle Veraart, Lucilio Cordero-Grande, Anthony N. Price, Jana Hutter, Joseph V. Hajnal, J-Donald Tournier   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Separating group- and individual-level brain signatures in the newborn functional connectome: A deep learning approach

NeuroImage
Recent studies indicate that differences in cognition among individuals may be partially attributed to unique brain wiring patterns. While functional connectivity (FC)-based fingerprinting has demonstrated high accuracy in identifying adults, early ...
Jung-Hoon Kim, Josepheen De Asis-Cruz, Catherine Limperopoulos   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation [PDF]

, 2013
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition.
Green, Alexander L, Zrinzo, L, Brittain, John-Stuart, Green, Alexander L., Aziz, Tipu, Green, AL, Zrinzo, Ludvic, Little, S, Cagnan, H, Little, Simon, Limousin, P, Fitzgerald, James, Cagnan, Hayrire, Foltynie, Thomas, Hariz, Marwan, Brittain, JS, Limousin, Patricia, Aziz, T, Brown, Peter, Joint, Carole, Fitzgerald, J, Hariz, M, Cagnan, Hayriye, Foltynie, T, Brown, P, Green, Alexander, Joint, C   +26 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perceived Control in the NICU: Implications for Maternal Mental Health and Parenting in the NICU

Psychology Research and Behavior Management
Mariana Cerqueira Aokalani,1 Katherine Leah Wisner,1,2 Julius Ngwa,1 Katherine Marie Ottolini,1,3,4 Nickie Niforatos Andescavage,1,3– 5 Catherine Limperopoulos1,4,5 1Developing Brain Institute, Children’s National Hospital, Washington, DC, USA ...
Aokalani MC, Wisner KL, Ngwa J, Ottolini KM, Andescavage NN, Limperopoulos C   +5 more
doaj