Results 61 to 70 of about 5,553,659 (298)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Baby Open Brains: An open-source dataset of infant brain segmentations

Scientific Data
Reproducibility of neuroimaging research on infant brain development remains limited due to highly variable processing approaches. Progress towards reproducible pipelines is limited by a lack of benchmarks such as gold-standard brain segmentations. These
Eric Feczko, Sally M. Stoyell, Lucille A. Moore, Dimitrios Alexopoulos, Maria Bagonis, Kenneth Barrett, Brad Bower, Addison Cavender, Taylor A. Chamberlain, Greg Conan, Trevor K. M. Day, Dhruman Goradia, Alice Graham, Lucas Heisler-Roman, Timothy J. Hendrickson, Audrey Houghton, Omid Kardan, Elizabeth A. Kiffmeyer, Erik G. Lee, Jacob T. Lundquist, Carina Lucena, Tabitha Martin, Anurima Mummaneni, Mollie Myricks, Pranav Narnur, Anders J. Perrone, Paul Reiners, Amanda R. Rueter, Hteemoo Saw, Martin Styner, Sooyeon Sung, Barry Tiklasky, Jessica L. Wisnowski, Essa Yacoub, Brett Zimmermann, Christopher D. Smyser, Monica D. Rosenberg, Damien A. Fair, Jed T. Elison   +38 more
doaj   +1 more source

Diminished Late Gestation Placental Volume in Fetal Heart Disease and Implications for Birth Anthropometrics

Journal of Cardiovascular Development and Disease
Background: The primary objective of this study was to compare the in vivo placenta volume across gestation in fetuses with congenital heart disease (CHD) and healthy controls.
Marin Jacobwitz, Kushal J. Kapse, Julius Ngwa, Josepheen De Asis-Cruz, Yao Wu, Rathinaswamy Govindan, Caitlin McDermott, Mary T. Donofrio, Adre du Plessis, Catherine Limperopoulos, Nickie Andescavage   +10 more
doaj   +1 more source

Organotypic Slice Culture of the Embryonic Mouse Brain

Bio-Protocol, 2020
Organotypic slice culture is a powerful technique for exploring the embryonic development of the mammalian brain. In this protocol we describe a basic slice culture technique we have used for two sets of experiments: axon guidance transplant assays and ...
James Clegg, Thomas Pratt
doaj   +1 more source

GESTATIONAL DEVELOPMENT OF BRAIN

Obstetrical & Gynecological Survey, 1978
Eighty normal human brains varying from 22 weeks' gestation to 1 month postnatal life were graded according to convolutional development and compared with the microscopical development of kidneys and the gestational age as given by the mother. Excellent correlation was obtained between the gross appearance of the brain and the microscopical appearance ...
K, Dorovini-Zis, C L, Dolman
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Molecular signatures of cortical expansion in the human foetal brain

Nature Communications
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this diversity ...
G. Ball, S. Oldham, V. Kyriakopoulou, L. Z. J. Williams, V. Karolis, A. Price, J. Hutter, M. L. Seal, A. Alexander-Bloch, J. V. Hajnal, A. D. Edwards, E. C. Robinson, J. Seidlitz   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Brain drain in developing countries [PDF]

Relying on an original data set on international migration by educational attainment for 1990 and 2000, we analyze the determinants of the brain drain from developing countries.
Abdeslam, MARFOUK, Olivier, LOHEST, Frederic, DOCQUIER   +2 more
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