Results 51 to 60 of about 5,553,659 (298)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Exploring the multiple-hit hypothesis of preterm white matter damage using diffusion MRI

NeuroImage: Clinical, 2018
Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk ...
Madeleine L. Barnett, Nora Tusor, Gareth Ball, Andrew Chew, Shona Falconer, Paul Aljabar, Jessica A. Kimpton, Nigel Kennea, Mary Rutherford, A. David Edwards, Serena J. Counsell   +10 more
doaj   +1 more source

An eye tracking based virtual reality system for use inside magnetic resonance imaging systems

Scientific Reports, 2021
Patients undergoing Magnetic Resonance Imaging (MRI) often experience anxiety and sometimes distress prior to and during scanning. Here a full MRI compatible virtual reality (VR) system is described and tested with the aim of creating a radically ...
Kun Qian, Tomoki Arichi, Anthony Price, Sofia Dall’Orso, Jonathan Eden, Yohan Noh, Kawal Rhode, Etienne Burdet, Mark Neil, A. David Edwards, Joseph V. Hajnal   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns

BMC Medical Genomics
Background Congenital heart disease (CHD) lesions are the most common birth defects and despite advances in care, are associated with short- and long-term co-morbidities.
Kristen Kocher, Julius Ngwa, Surajit Bhattacharya, Mary Donofrio, Catherine Limperopoulos, Nickie Andescavage   +5 more
doaj   +1 more source

Recent advances in diffusion neuroimaging: applications in the developing preterm brain [version 1; referees: 2 approved]

F1000Research, 2018
Measures obtained from diffusion-weighted imaging provide objective indices of white matter development and injury in the developing preterm brain. To date, diffusion tensor imaging (DTI) has been used widely, highlighting differences in fractional ...
Diliana Pecheva, Christopher Kelly, Jessica Kimpton, Alexandra Bonthrone, Dafnis Batalle, Hui Zhang, Serena J. Counsell   +6 more
doaj   +1 more source

Parental age effects on neonatal white matter development

NeuroImage: Clinical, 2020
Objective: Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial ...
Oliver Gale-Grant, Daan Christiaens, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Antonios Makropoulos, Nicholas Harper, Anthony N Price, Jana Hutter, Emer Hughes, Suresh Victor, Serena J Counsell, Daniel Rueckert, Joseph V Hajnal, A David Edwards, Jonathan O'Muircheartaigh, Dafnis Batalle   +16 more
doaj   +1 more source

The vulnerable developing brain [PDF]

Proceedings of the National Academy of Sciences, 2011
During healthy pregnancy, appropriate levels of fetal nutrition and oxygenation are indispensable for the optimal growth and development of the fetal organs. In pregnancy complicated by decreased nutrient and oxygen delivery to the fetus, current dogma is that the growth and development of key organs, such as the brain, are “spared” at the expense of ...
openaire   +2 more sources