Results 51 to 60 of about 2,326,033 (267)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Biodiversity buffers forest ecosystems from compound climate extremes

Nature Communications
Forest ecosystems provide key ecological, social, and climate benefits, yet their functions are potentially threatened by rising compound extremes characterised by simultaneous heat and drought or moisture excess.
Xuetao Qiao, Jakob Zscheischler, Michel Loreau, Peter B. Reich, Qingqing Chen, Michael Bahn, Neha Mohanbabu, Hannah J. White, Mingyu Luo, Shaopeng Wang   +9 more
doaj   +1 more source

Hybrid Label-Free Molecular Microscopies for Simultaneous Visualization of Changes in Cell Wall Polysaccharides of Peach at Single- and Multiple-Cell Levels during Postharvest Storage

Cells, 2020
Softening of fruit during the postharvest storage, which is mainly associated with both compositional and spatial changes of polysaccharides within cell wall, affects the texture and quality of fruit.
Weinan Huang, Yating Nie, Nan Zhu, Yifan Yang, Changqing Zhu, Minbiao Ji, Di Wu, Kunsong Chen   +7 more
doaj   +1 more source

Scratching the surface of skin development [PDF]

Nature, 2007
The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Antibody-based therapeutics and therapeutic development for diabetic retinopathy: targeting VEGF, Ang/Tie, and inflammatory pathways

Frontiers in Endocrinology
Diabetic retinopathy (DR), a leading cause of global blindness, represents a significant microvascular complication of diabetes mellitus. This comprehensive review examines the evolving landscape of monoclonal antibody (mAb) therapy in DR management. The
Yuan Zong, Yuan Zong, Yuan Zong, Shuang Qiu, Huang Zhang, Jiaxin Wu, Jiaxin Wu, Jingheng Du, Koju Kamoi, Zhimin Cen   +9 more
doaj   +1 more source

Superamphiphobic plastrons on wood and their effects on liquid repellence

Materials & Design, 2020
The increasing utilization of wood-based products raises new demands for improved durability, for example an enhanced liquid repellence. Superhydrophobic or superamphiphobic surfaces have been widely fabricated.
Haiyan Yin, Maziar Sedighi Moghaddam, Mikko Tuominen, Mimmi Eriksson, Mikael Järn, Andra Dėdinaitė, Magnus Wålinder, Agne Swerin   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source