Results 61 to 70 of about 2,326,033 (267)

On the parallel surfaces of the non-developable surfaces

BULLETIN OF THE KARAGANDA UNIVERSITY-MATHEMATICS, 2020
In the differential geometry of curves and surfaces, the curvatures of curves and surfaces are often calculated and results are given. In particular, the results given by using the apparatus of the curve - surface pair are important in terms of what kind of surface the surface indicates.
Ali ¸Cakmak, Yusuf Yaylı
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Experimental Insights into Hydraulic Jump Roller Length: The Impact of Compound Geometry, Slope, and Bed Roughness [PDF]

Journal of Applied Fluid Mechanics
This experimental investigation examines the relative roller length (Lr/h1) of hydraulic jumps taking place in composite rectangular channel featuring positive inclinations and roughened minor beds, aiming to address gaps in understanding the effects of ...
I. Herri, S. Kateb, A. Ghomri, H. Khechiba, D. Besser   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A 30-meter resolution global land productivity dynamics dataset from 2013 to 2022

Scientific Data
Land degradation is one of the most severe environmental challenges globally. To address its adverse impacts, the United Nations endorsed the Land Degradation Neutrality (SDG 15.3) within the Sustainable Development Goals in 2015.
Xiaosong Li, Tong Shen, Cesar Luis Garcia, Ingrid Teich, Yang Chen, Jin Chen, Amos Tiereyangn Kabo-Bah, Ziyu Yang, Xiaoxia Jia, Qi Lu, Mandakh Nyamtseren   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Spatio-temporal variations and multi-scale correlations of climate, water, land, and vegetation resources over the past four decades in the Heihe River Basin

Journal of Hydrology: Regional Studies
Study region: Heihe River Basin (HRB), Northwest China. Study focus: The study proposes an analytical scheme to identify trend, periodicity, and scale-correlation in climate, water, land, and vegetation resources over the past four decades using ...
Dandan Jiao, Shaomin Liu, Ziwei Xu, Lisheng Song, Yan Li, Rui Liu, Jiaxing Wei, Xinlei He, Dongxing Wu, Tongren Xu, Jingxin Guo   +10 more
doaj   +1 more source