Results 71 to 80 of about 225,907 (267)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Determining the Criteria and Their Weights for Medical Schools' Ranking: A National Consensus

Acta Medica Iranica, 2016
Delphi as a consensus development technique enables anonymous, systematic refinement of expert opinion with the aim of arriving at a combined or consensual position. In this study, we determined the criteria and their weights for Iranian Medical Schools'
Rita Mojtahedzadeh, Aeen Mohammadi, Noushin Kohan, Mitra Gharib, Mitra Zolfaghari   +4 more
doaj  

Multiple criteria assessment of a new tram line development scenario in Vilnius City public transport system

Transport, 2013
This paper considers the technological development of an additional network for Vilnius City public transport. Several types of scenarios for the development of Vilnius City tram line were analysed.
Marius Jakimavičius, Marija Burinskienė   +1 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Selection of bitter gourd (Momordica charantia L.) parental lines through line × tester analysis

Discover Agriculture
The identification of genetically diverse and high-performing parental lines is critical for the development of superior bitter gourd (Momordica charantia L.) hybrids. However, limited information is available on the combined morpho-genetic evaluation of
Farruk Ahamed, M. Hasanuzzaman, Md. Omar Kayess   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Uticaj efikasnosti upotrebe proizvodnih faktora na razlike u nivou razvijenosti jugoslovenskih regiona

Economic Analysis, 2019
This paper examines the link between economic efficiency and development level of the Yugoslav economy and its regions. The author presents the results of multicriteria ranking of economic regions according to the level of socio-economic development ...
Mlađan Dinkić
doaj   +2 more sources

THE APPLICATION OF THE PROMETHEE METHOD IN EVALUATION OF SUSTAINABLE DEVELOPMENT OF THE SELECTED CITIES IN POLAND

Economics and Environment, 2017
The priority objective of the article is the valuation of the selected Polish cities in the light of the sustainable development indicators, which have been developed by Central Statistical Offi ce of Poland.
Karolina Ogrodnik
doaj  

Methodology of Scientific, Transparent and Applicable Rankings for Chinese Guidelines and Consensus Related Literature Published in the Medical Journals: ample Identification and Speciality Assignment

Xiehe Yixue Zazhi
With the development of the Scientific, Transparent and Applicable Rankings tool for clinical practice guidelines(STAR), the publication of evaluation and ranking for scientificity, transparency and applicability of Chinese guidelines and consensus ...
LIU Hui, YANG Nan, SHI Qianling, LUO Xufei, ZHANG Hairong, TIAN Jinhui, JIN Yinghui, CHEN Yaolong, Methodology and Technology Specialisation Committee of the STAR Working Group   +8 more
doaj   +1 more source