Results 81 to 90 of about 1,212,018 (258)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Developing index of priority cooperation of Russian Federation in space industry with developing industries of Asia, Africa and Latin America

RUDN Journal of Economics, 2012
The article is devoted to the construction and practical approbation of the ranking methodology of developing countries of Asia, Africa and Latin America on the basis of priority for the Russian Federation to the cooperation development in the space ...
N V Dyuzheva, S A Balashova
doaj  

Multiple criteria assessment of a new tram line development scenario in Vilnius City public transport system

Transport, 2013
This paper considers the technological development of an additional network for Vilnius City public transport. Several types of scenarios for the development of Vilnius City tram line were analysed.
Marius Jakimavičius, Marija Burinskienė   +1 more
doaj   +1 more source

The current state and dynamics of regional disparities in Romania [PDF]

The paper aims to highlight the dynamics and current state of regional disparities in Romania, discussing both inter-regional disparities -between the eight development regions, corresponding to the NUTS II level- and intra-regional disparities -between ...
Bogdan Ileanu, Daniela-L. Constantin, Monica Roman, Zizi Goschin   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Methodology of Scientific, Transparent and Applicable Rankings for Chinese Guidelines and Consensus Related Literature Published in the Medical Journals: ample Identification and Speciality Assignment

Xiehe Yixue Zazhi
With the development of the Scientific, Transparent and Applicable Rankings tool for clinical practice guidelines(STAR), the publication of evaluation and ranking for scientificity, transparency and applicability of Chinese guidelines and consensus ...
LIU Hui, YANG Nan, SHI Qianling, LUO Xufei, ZHANG Hairong, TIAN Jinhui, JIN Yinghui, CHEN Yaolong, Methodology and Technology Specialisation Committee of the STAR Working Group   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

ECONOMIC MEASUREMENTS OF SOCIAL AND INTANGIBLE ASSETS: WHERE DOES ROMANIA STAND AT SUSTAINABLE DEVELOPMENT? [PDF]

Sustainable economic development, no matter the geographical area it is applied to, relates to improving living standards and incorporates a new focus and challenge for the economy: the measurement of intangible and social assets.
Alexandru Ghiţiu-Brătescu, Ioana Maria Ghidiu-Bîta, Suzana Elena Chiriac   +2 more
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A Development on AHP/DEA Methodology for Ranking Decision Making Units [PDF]

مدیریت صنعتی, 2011
The AHP/DEA methodology is an integration of Analytical Hierarchical Process (AHP) and Data Envelopment Analysis. This method uses the capabilities of both AHP and DEA. However, it has some problems: It illogically compares two decision-making units in a
Mohammad Reza Alirezayee, Mohammad Reza Rafiee Sani   +1 more
doaj