Results 101 to 110 of about 1,212,018 (258)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Determining the Criteria and Their Weights for Medical Schools' Ranking: A National Consensus
Acta Medica Iranica, 2016 Delphi as a consensus development technique enables anonymous, systematic refinement of expert opinion with the aim of arriving at a combined or consensual position. In this study, we determined the criteria and their weights for Iranian Medical Schools'
Rita Mojtahedzadeh +4 more
doaj
Lateral dampers for thrust bearings [PDF]
The development of lateral damping schemes for thrust bearings was examined, ranking their applicability to various engine classes, selecting the best concept for each engine class and performing an in-depth evaluation.
Hibner, D. H., Szafir, D. R.
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Ranking Mechanisms in Public Investment [PDF]
Properly spending the budget on public investments is the main issue of public authorities. The investment projects sustained by the state are very important for the entire socio-economic life.
Adriana GRIGORESCU, Andrei MOTOC
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
E-Commerce Applications Ranking [PDF]
The paper presents the cycle of development of e-Commerce applications. The e-commerce applications are analyzed being considered to be a subject for complex evaluations.
Marilena DUMITRACHE
core
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Core health indices during 2000-2007: a cpmarsion between Iran and other southwest Asian countries
Payesh, 2014 Objective (s): To compare health conditions in Iran and southwest Asian countries.Methods: Fifteen core health indices as reported by World Health Organization (WHO) for the period of 2000-2007 were listed for Iran and southwest Asain countires.
Abdalali Monsef, Abolfazl Shahmohammadi
doaj