Results 141 to 150 of about 19,882,836 (301)

Trends and status in resources security, ecological stability, and sustainable development research: a systematic analysis. [PDF]

Environ Sci Pollut Res Int, 2022
Kang X, Wang M, Lin J, Li X.
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mapping Intellectual Structure for the Long Non-Coding RNA in Hepatocellular Carcinoma Development Research. [PDF]

Front Genet, 2021
Lin Z, Ji X, Tian N, Gan Y, Ke L.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Implications of COVID-19 for safeguarding in international development research: learning, action and reflection from a research hub. [PDF]

BMJ Glob Health, 2022
Mansaray B, Dean L, Tubb P, Josyula KL, Okoth L, Chumo I, Waritu J, Klingel A, Manzoor F, Aktar B, Garimella S, Murthy S, Tolhurst R, Whittaker L, Gray L, Forsyth R, Elsey H, Waldman L, Theobald S.   +18 more
europepmc   +1 more source

The Financing of Research and Development [PDF]

Evidence on the "funding gap" for R&D is surveyed. The focus is on financial market reasons for underinvestment in R&D that persist even in the absence of externality-induced underinvestment.
Bronwyn H. Hall
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Evaluating official development assistance-funded granting mechanisms for global health and development research that is initiated in high-income countries. [PDF]

Health Res Policy Syst, 2022
Cassola A, Baral P, Røttingen JA, Hoffman SJ.   +3 more
europepmc   +1 more source

Electric vehicle battery research and development [PDF]

High energy battery technology for electric vehicles is reviewed. The state-of-the-art in conventional batteries, metal-gas batteries, alkali-metal high temperature batteries, and organic electrolyte batteries is ...
Schwartz, H. J.
core   +1 more source