FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The role of metabolic reprogramming in oocyte development: research progress and prospects. [PDF]
Front Reprod HealthLi Y, Liu Y, Jin J.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
New wealth through agricultural research and development: 86th annual report [PDF]
, 1967 Ohio Agricultural Research and Development Center
core
, 2015 This report summarises the key messages of 30 presentations with implications for research policy and practice under six key themes: economy, agriculture, natural resources, health, education and the ASEAN Economic Community (AEC).
Madhur, Srinivasa
core
Classification errors distort findings in automated speech processing: Examples and solutions from child-development research. [PDF]
Behav Res MethodsGautheron L +4 more
europepmc +1 more source
Mapping Intellectual Structure for the Long Non-Coding RNA in Hepatocellular Carcinoma Development Research. [PDF]
Front Genet, 2021 Lin Z, Ji X, Tian N, Gan Y, Ke L.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Better living through research and development: 90th annual report, 1971 [PDF]
, 1971 Ohio Agricultural Research and Development Center
core
From classroom to community: leveraging teacher professional development research to build capacity in community-based organizations. [PDF]
Front Public HealthKirk S +5 more
europepmc +1 more source