Results 121 to 130 of about 2,013,928 (265)

A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion system. [PDF]

J Appl Microbiol, 2022
Wu L, Li L, Yin X, Li C, Xin W, Liu L, Hua Z.   +6 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bench to bedside radiosensitizer development strategy for newly diagnosed glioblastoma. [PDF]

Radiat Oncol, 2021
Degorre C, Tofilon P, Camphausen K, Mathen P.   +3 more
europepmc   +1 more source

New Development Strategy: Development as Well-Being

, 2019
It is necessary to move from a paradigm of development as economic growth to one of development as well-being. It is vital to start thinking about development not in terms of greater income but in terms of people being satisfied with life. The paradigm shift needs to get rid of the notions of capital which are associated to the paradigm of progress as ...
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Future Development Strategy of Piezoelectric Devices. [PDF]

Micromachines (Basel)
Uchino K.
europepmc   +1 more source

Where Is the Way Forward for New Media Empowering Public Health? Development Strategy Options Based on SWOT-AHP Model. [PDF]

Int J Environ Res Public Health, 2022
Hao Z, Zhang M, Liu K, Zhang X, Jia H, Chen P.   +5 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Probiotic Development Strategy Centered on Stability and Regulatory Considerations. [PDF]

Compr Rev Food Sci Food Saf
Kim H, Haque MA, Razzak MA, Jang MJ, Song S, Ku S.   +5 more
europepmc   +1 more source

Determining the Development Strategy and Suited Adoption Paths for the Core Competence of Shared Decision-Making Tasks through the SAA-NRM Approach. [PDF]

Int J Environ Res Public Health, 2022
Yu SF, Wang HT, Chang MW, Cheng TT, Chen JF, Lin CL, Yu HT.   +6 more
europepmc   +1 more source