Results 121 to 130 of about 525,333 (255)

Editorial: Emerging frontiers in developmental biology in Latin America. [PDF]

Front Neurosci, 2023
Ortuño-Sahagún D, Riesgo-Escovar JR.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

How to lose a whorl: the evolutionary and developmental biology of apetaly. [PDF]

J Exp Bot
Cronk QCB.
europepmc   +1 more source

Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies. [PDF]

Front Cell Infect Microbiol, 2023
Cruz-Bustos T, Dolezal M, Feix AS, Ruttkowski B, Hummel K, Razzazi-Fazeli E, Joachim A.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

When imaging technology meets single-cell omics: new paradigm in developmental biology. [PDF]

Cell Regen
Wang C, Zhang X, Zhang Y, Liu F.
europepmc   +1 more source

Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology. [PDF]

Cell Mol Life Sci, 2023
Levin M.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Developmental Biology and Seasonal Damage of the Grape Borer <i>Xylotrechus pyrrhoderus</i> in Grapevines. [PDF]

Insects
Zhang G, Jia Y, Wu H, Zhang Y, Ghanim M, Ma Y, Sun R.   +6 more
europepmc   +1 more source

Advances and Challenges in Spatial Transcriptomics for Developmental Biology. [PDF]

Biomolecules, 2023
Choe K, Pak U, Pang Y, Hao W, Yang X.
europepmc   +1 more source