Results 111 to 120 of about 580,764 (305)

Mouse Models and the Evolutionary Developmental Biology of the Skull [PDF]

, 2010
Understanding development is relevant to understanding evolution because developmental processes structure the expression of phenotypic variation upon which natural selection acts.
Lieberman, Daniel, Hallgrímsson, Benedikt   +1 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Developmental Biology in Italy

, 2000
In the present paper, the Italian embryologists and their main contributions to this science before 1900 will be shortly reviewed. During the twentieth century, embryology became progressively integrated with cytology and histology and the new ...
SIRACUSA, GREGORIO, DE FELICI, MASSIMO, Siracusa,G, De Felici, M   +3 more
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Dictionary of Developmental Biology and Embryology, 2nd edition

, 2012
Developmental biology is the study of the mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, and genetic levels.
Dye, Frank
core  

Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition

, 2020
Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL).
Lyakisheva, Anna, Boxem, Mike, Jurisica, Igor, Kotlyar, Max, Tang, Priscilla, Sub Developmental Biology, Aboualizadeh, Farzaneh, Akula, Indira, Yao, Zhong, Stagljar, Igor, Kroll, Jason, Snider, Jamie, Developmental Biology   +12 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders

iScience
Summary: The classic view of the lysosome as a static recycling center has been replaced with one of a dynamic and mobile hub of metabolic regulation.
Jen-Jie Lee, Tong Wang, Kali Wiggins, Po Nien Lu, Christina Underwood, Katarzyna Ochenkowska, Eric Samarut, Laura M. Pollard, Heather Flanagan-Steet, Richard Steet   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

BCAS-3 is required for the progression of autophagosome formation to degrade paternal mitochondria in Caenorhabditis elegans

iScience
Summary: In the nematode Caenorhabditis elegans, autophagy degrades paternal mitochondria after fertilization to ensure the maternal inheritance of mitochondrial DNA.
Takuya Norizuki, Taeko Sasaki, Yuji Suehiro, Shohei Mitani, Waka Kojima, Koji Yamano, Noriyuki Matsuda, Miyuki Sato   +7 more
doaj   +1 more source