Results 191 to 200 of about 2,742,900 (350)

Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish

Development, 2017
H. McCauley, James M. Wells
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies. [PDF]

Front Cell Infect Microbiol, 2023
Cruz-Bustos T, Dolezal M, Feix AS, Ruttkowski B, Hummel K, Razzazi-Fazeli E, Joachim A.   +6 more
europepmc   +1 more source

Gravitational Biology Facility on Space Station: Meeting the needs of space biology [PDF]

The Gravitational Biology Facility (GBF) is a set of generic laboratory equipment needed to conduct research on Space Station Freedom (SSF), focusing on Space Biology Program science (Cell and Developmental Biology and Plant Biology).
Allen, Katherine, Wade, Charles
core   +1 more source

Novel Biocompatible Ultrananocrystalline Diamond (UNCD) Coating Technology for a New Generation of Medical Implants, Devices, and Scaffolds for Developmental Biology

, 2017
Orlando Auciello
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology. [PDF]

Cell Mol Life Sci, 2023
Levin M.
europepmc   +1 more source

Gene transfer into chicken embryos as an effective system of analysis in developmental biology [PDF]

, 2000
Sadao Yasugi, Harukazu Nakamura
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

USSR Space Life Sciences Digest, issue 13 [PDF]

This is the thirteenth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 39 papers recently published in Russian-language periodicals and bound collections, two papers delivered at an international life sciences symposium, and ...
Hooke, Lydia Razran, Teeter, Ronald, Teeter, Ronald, Teeter, Ronald, Teeter, Ronald   +4 more
core   +1 more source