Results 81 to 90 of about 1,093,837 (334)

Loss of miR-29a impairs decidualization of endometrial stromal cells by TET3 mediated demethylation of Col1A1 promoter

iScience, 2021
Summary: A conceptual framework for understanding abnormal endometrial decidualization, with considerable significance for the diagnosis and treatment of abnormal decidualization-related changes in non-receptive endometrium in implantation failure during
Aixia Liu, Mengmeng Jin, Laidi Xie, Mengyu Jing, Ying Zhou, Minyue Tang, Tingting Lin, Dimin Wang   +7 more
doaj  

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Evo-devo of human adolescence: beyond disease models of early puberty [PDF]

, 2013
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton, AB Arquitt, AB Migliano, AK Pesonen, AS Parent, B Bogin, B Campbell, BH Smith, BJ Ellis, BJ Ellis, BJ Ellis, BJ Ellis, BS Zemel, C Ankarberg Lindgren, C Cooper, C Tardieu, CC Chen, CL Sisk, F Deng, GB Cutler Jr, GB Muller, GE Weisfeld, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Bowlby, J Bowlby, J James, J Tinggaard, Jay Belsky, JC Wingfield, JL Locke, JM Tither, KB Simondon, KK Ong, KK Ong, KO Klein, L Aksglaede, LA Proos, M Celio, M Del Giudice, M Krstevska-Konstantinova, M Mead, M Suzuki, ME Pembrey, MR Palmert, N Howell, NM Cameron, PD Gluckman, PD Kroboth, PJ Hunt, RG Westendorp, S White, SB Manuck, SC Stearns, W Arlt, W Copeland, WT Boyce, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Ze'ev Hochberg   +69 more
core   +2 more sources

Protocol to detect smooth muscle actin-alpha and measure oxidative damage in neonatal mouse intestine

STAR Protocols, 2022
Summary: This protocol describes how to characterize α-Smooth muscle actin (αSMA) spatiotemporal expression during mouse small intestinal development.
Shing Hu, Carolyn S. Sevier, Natasza A. Kurpios   +2 more
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Reproductive tract biology: Of mice and men. [PDF]

, 2019
The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology.
Baskin, Laurence S, Cao, Mei, Cunha, Gerald R, Ricke, Will A, Robboy, Stanley J, Sinclair, Adriane   +5 more
core  

Developmental regulation of oocyte lipid intake through ‘patent’ follicular epithelium in Drosophila melanogaster

iScience, 2021
Summary: Epithelia form protective permeability barriers that selectively allow the exchange of material while maintaining tissue integrity under extreme mechanical, chemical, and bacterial loads. Here, we report in the Drosophila follicular epithelium a
Sarayu Row, Yi-Chun Huang, Wu-Min Deng
doaj  

The Machine Conception of the Organism in Development and Evolution: A Critical Analysis [PDF]

, 2014
This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for ...
Nicholson, Daniel J.
core  

Single cell expression analysis of primate-specific retroviruses-derived HPAT lincRNAs in viable human blastocysts identifies embryonic cells co-expressing genetic markers of multiple lineages

Heliyon, 2018
Chromosome instability and aneuploidies occur very frequently in human embryos, impairing proper embryogenesis and leading to cell cycle arrest, loss of cell viability, and developmental failures in 50–80% of cleavage-stage embryos.
Gennadi Glinsky, Jens Durruthy-Durruthy, Mark Wossidlo, Edward J. Grow, Jason L. Weirather, Kin Fai Au, Joanna Wysocka, Vittorio Sebastiano   +7 more
doaj  

Horizontal mtDNA transfer between cells is common during mouse development

iScience, 2022
Summary: Cells transmit their genomes vertically to daughter cells during cell divisions. Here, we demonstrate the occurrence and extent of horizontal mitochondrial (mt)DNA acquisition between cells that are not in a parent-offspring relationship ...
Nuria Marti Gutierrez, Aleksei Mikhalchenko, Hong Ma, Amy Koski, Ying Li, Crystal Van Dyken, Rebecca Tippner-Hedges, David Yoon, Dan Liang, Tomonari Hayama, David Battaglia, Eunju Kang, Yeonmi Lee, Anthony Paul Barnes, Paula Amato, Shoukhrat Mitalipov   +15 more
doaj