Results 81 to 90 of about 608,296 (310)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells

iScience, 2023
Summary: Cochlear and vestibular hair cells are highly specialized sensory receptors for hearing and balance. Here, we report a serendipitous identification of a hair-cell-specific organelle in neonatal mouse inner ear, which we name “apicosome.” The ...
Xiaofen Li, Qirui Zhao, Xiaojie Yu, Wenhan Cao, Yingyi Zhang, Wanying Feng, Liwen Jiang, David Z. He, Robert Z. Qi, Pingbo Huang   +9 more
doaj  

Ecological Developmental Biology: Developmental Biology Meets the Real World

Developmental Biology, 2001
The production of phenotype is regulated by differential gene expression. However, the regulators of gene expression need not all reside within the embryo. Environmental factors, such as temperature, photoperiod, diet, population density, or the presence of predators, can produce specific phenotypes, presumably by altering gene-expression patterns. The
openaire   +5 more sources

Developmental biology of lichens [PDF]

New Phytologist, 1993
SUMMARYLichen‐forming fungi are a large, taxonomically diverse group of nutritional specialists which acquire fixed carbon from a population of minute green algal or cyanobacterial cells. Mycobionts of foliose or fruticose lichens differ from the rest of the fungi by expressing morphologically and anatomically complex symbiotic phenotypes.
openaire   +3 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Sox9 regulates melanocytic fate decision of adult hair follicle stem cells

iScience, 2023
Summary: The bulge of hair follicles harbors Nestin+ (neural crest like) stem cells, which exhibit the potential to generate various cell types including melanocytes.
Isabel Stüfchen, Felix Beyer, Sebastian Staebler, Stefan Fischer, Melanie Kappelmann, Ruth Beckervordersandforth, Anja K. Bosserhoff   +6 more
doaj  

Genetics and developmental biology of cooperation [PDF]

Molecular Ecology, 2017
AbstractDespite essential progress towards understanding the evolution of cooperative behaviour, we still lack detailed knowledge about its underlying molecular mechanisms, genetic basis, evolutionary dynamics and ontogeny. An international workshop “Genetics and Development of Cooperation,” organized by the University of Bern (Switzerland), aimed at ...
Filipa Cunha-Saraiva, Min Wu, Stefan Fischer, Aura Raulo, Ulrich R. Ernst, Maddalena Vierbuchen, Claudia Kasper, Kenyon B. Mobley, Kenyon B. Mobley, Barbara Taborsky, Reinder Radersma   +10 more
openaire   +4 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Form, function, mind: what doesn't compute (and what might) [PDF]

arXiv, 2023
The applicability of computational and dynamical systems models to organisms is scrutinized, using examples from developmental biology and cognition. Developmental morphogenesis is dependent on the inherent material properties of developing tissues, a non-computational modality, but cell differentiation, which utilizes chromatin-based revisable memory ...
arxiv  

Developmental Biology: Tension at the Border [PDF]

Current Biology, 2009
A combination of biophysical measurements and computer simulation shows that a localised increase in cell bond tension prevents cell mixing at the anterior-posterior compartment boundary of Drosophila wing imaginal discs.
Jean-Paul Vincent, David Irons
openaire   +3 more sources