Results 91 to 100 of about 562,551 (304)

No evidence for inhibitory deficits or altered reward processing in ADHD: data from a new integrated incentive delay go/no-go task [PDF]

, 2016
Objective: Cognitive and motivational factors differentially affect individuals with mental health problems such as ADHD. Here we introduce a new task to disentangle the relative contribution of inhibitory control and reward anticipation on task ...
Barke, Edmund, Demurie, Ellen, Roeyers, Herbert, Wiersema, Roeljan   +3 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Language growth in very young siblings at risk for autism spectrum disorder [PDF]

, 2019
Background Children with autism spectrum disorder (ASD) show substantial variability in their language development. Language problems are highly prevalent in these children.
Beyers, Wim, Bontinck, Chloè, Boterberg, Sofie, Bruyneel, Eva, Demurie, Ellen, Dewaele, Nele, Roeyers, Herbert, Warreyn, Petra   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Developing a Sufficient Knowledge Base for Faces: Implicit Recognition Memory for Distinctive versus Typical Female Faces [PDF]

, 2005
Research on adults' face recognition abilities provides evidence for a distinctiveness effect such that distinctive faces are remembered better and more easily than typical faces. Research on this effect in the developmental literature is limited. In the
Best, Catherine A.
core  

Training programs for 5-9 (10) classes of special secondary schools for children with developmental delay. World Literature classes 5 [PDF]

Зміст навчальної програми побудовано відповідно до вимог Державного стандарту базової і повної загальної середньої освіти та укладено на основі адаптації державних вимог до загальноосвітньої підготовки дітей із затримкою психічного розвитку. Упровадження
Омельченко, Ірина Миколаївна
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The motivating operation and negatively reinforced problem behavior. A systematic review. [PDF]

, 2014
The concept of motivational operations exerts an increasing influence on the understanding and assessment of problem behavior in people with intellectual and developmental disability. In this systematic review of 59 methodologically robust studies of the
Borthwick-Duffy S. A., Carey Y. A., Edrisinha C. E., Kennedy C. H., Miltenberger R. G., Oliver C., Rusch R. G., Scotti J. R.   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source