Results 41 to 50 of about 219,778 (217)

Neuropsychomotor developmental delay: conceptual map, term definitions, uses and limitations

Revista Paulista de Pediatria, 2015
OBJECTIVE: To retrieve the origin of the term neuropsychomotor developmental delay" (NPMD), its conceptual evolution over time, and to build a conceptual map based on literature review. DATA SOURCE: A literature search was performed in the SciELO Brazil,
Lílian de Fátima Dornelas, Neuza Maria de Castro Duarte, Lívia de Castro Magalhães   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey

Child and Adolescent Psychiatry and Mental Health
Background Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool ...
Dan Long, Ting Yang, Jie Chen, Jie Zhang, Ying Dai, Li Chen, Feiyong Jia, Lijie Wu, Yan Hao, Ling Li, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Tingyu Li   +18 more
doaj   +1 more source

Age of Entry into Early Intervention: Influence of the COVID-19 Pandemic, Telehealth, and Other Factors

Journal of Pediatrics: Clinical Practice
Objective: To evaluate the extent to which age of early intervention (EI) enrollment was influenced by policy changes associated with the introduction of telehealth and hybrid service delivery models into a statewide EI system across COVID-19 periods ...
Lauren M. Little, PhD, OTR/L, FAOTA, Sheerah Neal Keith, PhD, LMHC-S, LPC, NCC, BC- TMH, Anna Wallisch, PhD, OTR/L, FAOTA, Beth S. Rous, EdD, Tricia Johnson, PhD, Waylon J. Howard, PhD, Scott Tomchek, PhD, OTR/L, FAOTA   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

PENGARUH TERAPI LATIHAN PADA DEVELOPMENTAL DELAY

Jurnal Fisioterapi dan Rehabilitasi, 2018
Latar Belakang : Prevalensi keterlambatan perkembangan motorik yang signifikan di dalam populasi anak tidak diketahui. Melalui perhitungan statistik, 2-3% bayi berada di luar rentang tonggak pencapaian motorik normal. Dari angka tersebut, sebagian kecil (
Suci Amanati, Didik Purnomo, Zainal Abidin, Irawan Wibisono   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Expanding the mutational spectrum of ZTTK syndrome: A de novo variant with global developmental delay and malnutrition in a Chinese patient

Molecular Genetics & Genomic Medicine, 2023
Background Zhu‐Tokita‐Takenouchi‐Kim (ZTTK, OMIM 617140) syndrome is a severe multisystem developmental disorder characterized by intellectual disability, developmental delay, cortical malformations, epilepsy, visual problems, musculoskeletal ...
Shuo Tang, Jieyu You, Li Liu, Hongjuan Ouyang, Na Jiang, Jiaqi Duan, Canlin Li, Yanhong Luo, Wenting Zhang, Meizheng Zhan, Chenxi Liu, Gui‐Zhen Lyu, Victor Wei Zhang, Hongmei Zhao   +13 more
doaj   +1 more source