Results 261 to 270 of about 823,004 (286)
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Molecular and developmental mechanisms of congenital heart valve disease
Birth Defects Research Part A: Clinical and Molecular Teratology, 2011AbstractCongenital heart disease occurs in approximately 1% of all live births and includes structural abnormalities of the heart valves. However, this statistic underestimates congenital valve lesions, such as bicuspic aortic valve (BAV) and mitral valve prolapse (MVP), that typically become apparent later in life as progressive valve dysfunction and ...
Joy, Lincoln, Katherine E, Yutzey
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MOLECULAR MECHANISMS IN DEVELOPMENTAL BIOLOGY
Cell Biology International, 1996AbstractSome general molecular mechanisms underlying development are described. Namely: those involved in the differentiation of the R7 receptor inDrosophilaembryonic retina; those involved in the determination of embryonic axes and in polar cell differentiation, inDrosophila; those involved in the determination of the AB and P cell lineage and in ...
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Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications
Journal of Molecular Medicine, 1997Industrial chemicals and environmental pollutants can disrupt reproductive development in wildlife and humans by mimicking or inhibiting the action of the gonadal steroid hormones, estradiol and testosterone. The toxicity of these so-called environmental endocrine disruptors is especially insidious during sex differentiation and development due to the ...
W R, Kelce, E M, Wilson
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Genomic imprinting: developmental significance and molecular mechanism
Current Opinion in Genetics & Development, 1991Imprinting results in the preferential expression of either the maternal or the paternal allele of certain genes, and has a critical influence on the regulation of mammalian development. The identification of specific imprinted chromosomal regions and genes is being used to unravel the molecular mechanism of imprinting and the developmental ...
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Developmental Effects and Molecular Mechanisms of Environmental Antiandrogens
1998Industrial chemicals and environmental pollutants can disrupt reproductive development in wildlife and humans by altering the synthesis, transport, action, or elimination of gonadal steroid hormones. Steroid hormones control fundamental events in embryonic development and sex differentiation by binding to their cognate nuclear receptors, which act as ...
William R. Kelce, Elizabeth M. Wilson
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Molecular Mechanisms of Crude Oil Developmental Toxicity in Fish
Archives of Environmental Contamination and Toxicology, 2017With major oil spills in Korea, the United States, and China in the past decade, there has been a dramatic increase in the number of studies characterizing the developmental toxicity of crude oil and its associated polycyclic aromatic compounds (PACs).
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Molecular Mechanisms of Human Embryogenesis: Developmental Pathogenesis of Renal Tract Malformations
Pediatric and Developmental Pathology, 2002The focus of this review is the normal and abnormal development of the kidney and lower urinary tract; for convenience, we will refer to the whole system as the renal tract. The content represents a convergence among the clinical disciplines of histopathology, nephrology, and urology as well the basic sciences of developmental biology and molecular ...
Woolf, A.S., Winyard, P.J.D.
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Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation
Seminars in Cancer Biology, 2022Cancer research has been largely focused on the cellular and molecular levels of investigation. Recent data show that not only the cell but also the extracellular matrix plays a major role in the progression of malignancy. In this way, the cells and the extracellular matrix create a specific local microenvironment that supports malignant development ...
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Molecular-genetic mechanisms of the effect of developmental hormones in insects
Russian Journal of Developmental Biology, 2007A review of the available data on molecular mechanisms underlying the regulation of gene expression by the developmental hormone ecdysone and juvenile hormone. Heterodimer ESP/USP is the main ecdysone receptor in D. melanogaster. Structures similar to ESP/USP were found in other insects.
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Environmental Science & Technology, 2017
Developmental toxicity is a critical issue in nanotoxicity. However, very little is known about the effects of graphene oxide (GO, a widely used carbon material) at predicted environmental concentrations on biological development or the specific molecular mechanisms.
Xingli Zhang +3 more
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Developmental toxicity is a critical issue in nanotoxicity. However, very little is known about the effects of graphene oxide (GO, a widely used carbon material) at predicted environmental concentrations on biological development or the specific molecular mechanisms.
Xingli Zhang +3 more
openaire +2 more sources