Results 31 to 40 of about 181,058 (246)

Evo-devo of human adolescence: beyond disease models of early puberty [PDF]

, 2013
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton, AB Arquitt, AB Migliano, AK Pesonen, AS Parent, B Bogin, B Campbell, BH Smith, BJ Ellis, BJ Ellis, BJ Ellis, BJ Ellis, BS Zemel, C Ankarberg Lindgren, C Cooper, C Tardieu, CC Chen, CL Sisk, F Deng, GB Cutler Jr, GB Muller, GE Weisfeld, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Bowlby, J Bowlby, J James, J Tinggaard, Jay Belsky, JC Wingfield, JL Locke, JM Tither, KB Simondon, KK Ong, KK Ong, KO Klein, L Aksglaede, LA Proos, M Celio, M Del Giudice, M Krstevska-Konstantinova, M Mead, M Suzuki, ME Pembrey, MR Palmert, N Howell, NM Cameron, PD Gluckman, PD Kroboth, PJ Hunt, RG Westendorp, S White, SB Manuck, SC Stearns, W Arlt, W Copeland, WT Boyce, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Ze'ev Hochberg   +69 more
core   +2 more sources

Developmental plasticity of CNS microglia [PDF]

Proceedings of the National Academy of Sciences, 2001
Microglia arise from CD45 + bone marrow precursors that colonize the fetal brain and play a key role in central nervous system inflammatory conditions. We report that parenchymal microglia are uncommitted myeloid progenitors of immature dendritic cells and macrophages by several criteria, including surface ...
L, Santambrogio, S L, Belyanskaya, F R, Fischer, B, Cipriani, C F, Brosnan, P, Ricciardi-Castagnoli, L J, Stern, J L, Strominger, R, Riese   +8 more
openaire   +2 more sources

What can developmental disorders tell us about the neurocomputational constraints that shape development? the case of Williams syndrome [PDF]

, 2003
The uneven cognitive phenotype in the adult outcome of Williams syndrome has led some researchers to make strong claims about the modularity of the brain and the purported genetically determined, innate specification of cognitive modules.
Karmiloff-Smith, Annette, Thomas, Michael S.C.   +1 more
core   +3 more sources

Developmental Plasticity of Inhibitory Circuitry [PDF]

The Journal of Neuroscience, 2006
In 1949, Donald Hebb proposed a mechanism for use-dependent synaptic plasticity, suggesting that input neurons that reliably activate their postsynaptic target will strengthen their connections ([Hebb, 1949][1]).
Sarah L, Pallas, Peter, Wenner, Carlos, Gonzalez-Islas, Michela, Fagiolini, Khaleel A, Razak, Gunsoo, Kim, Dan, Sanes, Birgit, Roerig   +7 more
openaire   +2 more sources

Early gait development in human infants: Plasticity and clinical applications [PDF]

, 2015
In this paper we focus on how a developmental perspective on plasticity in the control of human movement can promote early therapy and improve gait acquisition in infants with developmental disabilities.
Lee, Do Kyeong, Teulier, Caroline, Ulrich, Beverly D.   +2 more
core   +2 more sources

RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models

EMBO Molecular Medicine, 2018
Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia.
Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani   +16 more
doaj   +1 more source

Age and size at maturity: sex, environmental variability and developmental thresholds [PDF]

, 2004
In most organisms, transitions between different life-history stages occur later and at smaller sizes as growth conditions deteriorate. Day and Rowe recently proposed that this pattern could be explained by the existence of developmental thresholds ...
Andrew P. Beckerman, Craig T. Lapsley, Day T., Stewart J. Plaistow, Tim G. Benton, Wesselingh R. A.   +5 more
core   +2 more sources

Gestational Hypoxia and Developmental Plasticity [PDF]

Physiological Reviews, 2018
Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned with the transduction of hypoxia-induced responses.
Charles A, Ducsay, Ravi, Goyal, William J, Pearce, Sean, Wilson, Xiang-Qun, Hu, Lubo, Zhang   +5 more
openaire   +2 more sources

Physiological mechanisms of adaptive developmental plasticity in Rana temporaria island populations

BMC Evolutionary Biology, 2017
Background Adaptive plasticity is essential for many species to cope with environmental heterogeneity. In particular, developmental plasticity allows organisms with complex life cycles to adaptively adjust the timing of ontogenetic switch points. Size at
Pablo Burraco, Ana Elisa Valdés, Frank Johansson, Ivan Gomez-Mestre   +3 more
doaj   +1 more source

Developmental plasticity [PDF]

Evolution, Medicine, and Public Health, 2017
Amanda J Lea, Jenny Tung, Elizabeth A Archie, Susan C Alberts   +3 more
  +7 more sources