Topological isolation of developmental regulators in mammalian genomes [PDF]
Nature Communications, 2021 The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation ...
Hua-Jun Wu +6 more
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Toward artificial developmental regulators [PDF]
Journal of the American Chemical Society, 2003 A polyamide-peptide conjugate is designed which recruits sequence specifically the developmental regulator Exd to a cognate DNA site. In particular, an eight-ring hairpin polyamide (Im-Im-Py(C3H6NHR)-Py-gamma-Im-Py-Py-Py-beta-Dp) with a heptapeptide (R =
Ansari, Aseem Z. +5 more
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Application of Developmental Regulators for Enhancing Plant Regeneration and Genetic Transformation [PDF]
PlantsEstablishing plant regeneration systems and efficient genetic transformation techniques plays a crucial role in plant functional genomics research and the development of new crop varieties.
Pingjun Xu +9 more
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Functional Mechanisms and the Application of Developmental Regulators for Improving Genetic Transformation in Plants [PDF]
PlantsEnhancing the genetic transformation efficiency of major crops remains a significant challenge, primarily due to their suboptimal regeneration efficiency.
Yilin Jiang, Siyuan Liu, Xueli An
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microRNAs as Developmental Regulators. [PDF]
Cold Spring Harb Perspect Biol, 2015 The field of miRNA biology is relatively young, but its impact on our understanding of the regulation of a wide array of cell functions is far-reaching. The importance of miRNAs in development has become nearly ubiquitous, with miRNAs contributing to development of most cells and organs.
Ivey KN, Srivastava D.
europepmc +6 more sources
Redox modulation of plant developmental regulators from the class I TCP transcription factor family [PDF]
, 2013 TEOSINTE BRANCHED1-CYCLOIDEA-PROLIFERATING CELL FACTOR1 (TCP) transcription factors participate in plant developmental processes associated with cell proliferation and growth.
Gonzalez, Daniel Hector +2 more
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Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators [PDF]
Nature Communications, 2019 Despite the crucial physiological processes governed by neurons in the hypothalamic arcuate nucleus (ARC), the developmental pathways and regulators for ARC neurons remain understudied.
Christian Huisman +9 more
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Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation [PDF]
mBio, 2019 Glycosomes are peroxisome-related organelles that compartmentalize the glycolytic enzymes in kinetoplastid parasites. These organelles are developmentally regulated in their number and composition, allowing metabolic adaptation to the parasite’s needs in
Balázs Szöőr +7 more
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A mutant O-GlcNAcase enriches Drosophila developmental regulators. [PDF]
Nat Chem Biol, 2017 YesProtein O-GlcNAcylation is a reversible post-translational modification of serines/threonines on nucleocytoplasmic proteins. It is cycled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (O-GlcNAcase or OGA).
Selvan N +10 more
europepmc +5 more sources
Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy [PDF]
Nature Communications, 2019 The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.
Franziska Fröb +8 more
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