Results 101 to 110 of about 357,386 (324)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast?

Cells
Cells must change their properties in order to adapt to a constantly changing environment. Most of the cellular sensing and regulatory mechanisms described so far are based on proteins that serve as sensors, signal transducers, and effectors of ...
Michal Čáp, Zdena Palková
doaj   +1 more source

The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis [PDF]

, 2009
Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell ...
Abraham, Affolter, Ambros, Antebi, Asahina, Blelloch, Brenner, Cardoso, Chamberlin, Chisholm, Chitwood, DeMeo, Duchek, Euling, Fernandes, Ferreira, Gaudet, Gaudet, Ghysen, Gissendanner, Henderson, Henderson, Hoch, Hodgkin, Hollemann, Kamath, Kimble, Kitambi, Klass, Kuntz, Lehmann, Lucanic, Lundquist, Maduro, Margolis, Meighan, Meighan, Monaghan, Montell, Moss, Motola, Nettles, Ou, Pankratz, Pearson, Pignoni, Randall, Robson, Roy, Sarin, Sauka-Spengler, Siegfried, Su, Sulston, Sulston, Towers, Vogel, Wang, Younossi-Hartenstein, Yu, Ziel, Zipkin   +61 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genome-Wide Analysis of Gene Expression during Early Arabidopsis Flower Development [PDF]

, 2005
Detailed information about stage-specific changes in gene expression is crucial for the understanding of the gene regulatory networks underlying development.
Alves-Ferreira, Márcio, Dubois, Annick, Meyerowitz, Elliot M., Riechmann, José Luis, Wellmer, Frank   +4 more
core   +5 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A single-cell and tissue-scale analysis suite resolves Mixl1’s role in heart development

iScience
Summary: Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development. However, large-scale studies dissecting the molecular role of development master regulators in every cell type ...
Magdalena E. Strauss, Mai-Linh Nu Ton, Samantha Mason, Jaana Bagri, Luke T.G. Harland, Ivan Imaz-Rosshandler, Nicola K. Wilson, Jennifer Nichols, Richard C.V. Tyser, Berthold Göttgens, John C. Marioni, Carolina Guibentif   +11 more
doaj   +1 more source