Results 121 to 130 of about 357,386 (324)
Hypoxia Is a Developmental Regulator in Plant Meristems [PDF]
, 2019 Anne‐Laure Le Gac, Thomas Laux
openalex +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Novel Plant Growth Regulators and their Potential Uses in Agriculture
International Journal of Bio-Resource and Stress Management, 2017 Phytohormones or plant growth regulators play a crucial role in plant growth and developmental process. Apart from the traditional plant hormones studied so far i.e., auxin, gibberellins, cytokinin, abscisic acid, and ethylene, various other ...
Ankita Mishra, Debasish Panda
doaj
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Retrospective on U.S. Health Risk Assessment: How Others Can Benefit [PDF]
, 1995 Dr. Paustenbach reviews the scientific underpinnings of about twenty years of health risk assessment practice and their implications for environmental policy.
Paustenbach, Dennis J.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A negative regulator linking chromosome segregation to developmental transcription in Bacillus subtilis [PDF]
, 1998 Marguerite A. Cervin +5 more
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
Nature Communications, 2019 Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human ...
Wenliang Zhu +9 more
doaj +1 more source
H3K4me2 ChIP-Seq reveals the epigenetic landscape during mushroom formation and novel developmental regulators of Schizophyllum commune. [PDF]
Sci Rep, 2021 Vonk PJ, Ohm RA.
europepmc +1 more source