Results 131 to 140 of about 165,041 (290)

Evolution of vascular plants through redeployment of ancient developmental regulators. [PDF]

Proc Natl Acad Sci U S A, 2020
Lu KJ, van 't Wout Hofland N, Mor E, Mutte S, Abrahams P, Kato H, Vandepoele K, Weijers D, De Rybel B.   +8 more
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

The Nuclear Actin-Related Protein ARP6 Is a Pleiotropic Developmental Regulator Required for the Maintenance ofFLOWERING LOCUS CExpression and Repression of Flowering inArabidopsis w⃞ [PDF]

, 2005
Roger B. Deal, Muthugapatti K. Kandasamy, Elizabeth C. McKinney, Richard B. Meagher   +3 more
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes

Cellular & Molecular Biology Letters
Diabetes mellitus is a complex metabolic disorder characterized by hyperglycemia due to impaired insulin production, action, or both. The Pancreas and Liver play central roles in glucose regulation, and their dysfunction is critical to the onset and ...
Simona S. Ghanem, Tara Al-Barazenji, Rehab Badi, Essam M. Abdelalim   +3 more
doaj   +1 more source

Author Correction: Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators. [PDF]

Nat Commun, 2020
Huisman C, Cho H, Brock O, Lim SJ, Youn SM, Park Y, Kim S, Lee SK, Delogu A, Lee JW.   +9 more
europepmc   +1 more source

Environmental and developmental signals modulate proline homeostasis: evidence for a negative transcriptional regulator.

, 1996
Nathalie Verbruggen, Xue Jun Hua, Mike May, Marc Van Montagu   +3 more
openalex   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

The microRNA miR‐33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster [PDF]

, 2021
Laure‐Alix Clerbaux, Hayley T. Schultz, Samara Roman-Holba, Dan Fu Ruan, Ronald Yu, Abigail M. Lamb, Guido T. Bommer, Jennifer A. Kennell   +7 more
openalex   +1 more source