Results 11 to 20 of about 334,033 (329)

Toward Artificial Developmental Regulators [PDF]

Journal of the American Chemical Society, 2003
A polyamide-peptide conjugate is designed which recruits sequence specifically the developmental regulator Exd to a cognate DNA site. In particular, an eight-ring hairpin polyamide (Im-Im-Py(C3H6NHR)-Py-gamma-Im-Py-Py-Py-beta-Dp) with a heptapeptide (R = Ac-Phe-Tyr-Pro-Trp-Met-Lys-Gly-) attached on a central ring was shown to induce cooperative binding
Hans‐Dieter Arndt, Karl E. Hauschild, David P. Sullivan, Kara Lake, Peter B. Dervan, Aseem Z. Ansari   +5 more
core   +9 more sources

Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements [PDF]

Stem Cells and Cloning: Advances and Applications, 2009
Michael L Levy1, Allen L Ho1,2, Samuel Hughes3, Jayant Menon1, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute ...
Michael L Levy, Allen L Ho, Samuel Hughes, Jayant Menon, Rahul Jandial   +4 more
doaj   +5 more sources

microRNAs as Developmental Regulators. [PDF]

Cold Spring Harb Perspect Biol, 2015
The field of miRNA biology is relatively young, but its impact on our understanding of the regulation of a wide array of cell functions is far-reaching. The importance of miRNAs in development has become nearly ubiquitous, with miRNAs contributing to development of most cells and organs.
Ivey KN, Srivastava D.
europepmc   +6 more sources

A mutant O-GlcNAcase enriches Drosophila developmental regulators. [PDF]

Nat Chem Biol, 2017
YesProtein O-GlcNAcylation is a reversible post-translational modification of serines/threonines on nucleocytoplasmic proteins. It is cycled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (O-GlcNAcase or OGA).
Selvan N, Williamson R, Mariappa D, Campbell DG, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF.   +10 more
europepmc   +5 more sources

Vascular Regulation of Developmental Neurogenesis

Frontiers in Cell and Developmental Biology, 2022
Evolutionary studies indicate that the nervous system evolved prior to the vascular system, but the increasing complexity of organisms prompted the vascular system to emerge in order to meet the growing demand for oxygen and nutrient supply. In recent years, it has become apparent that the symbiotic communication between the nervous and the vascular ...
Johanna Vogenstahl, Johanna Vogenstahl, Marta Parrilla, Amparo Acker-Palmer, Amparo Acker-Palmer, Amparo Acker-Palmer, Marta Segarra, Marta Segarra   +7 more
openaire   +3 more sources

Callose homeostasis at plasmodesmata: molecular regulators and developmental relevance [PDF]

, 2014
Plasmodesmata are membrane-lined channels that are located in the plant cell wall and that physically interconnect the cytoplasm and the endoplasmic reticulum (ER) of adjacent cells.
De Storme, Nico, Geelen, Danny
core   +6 more sources

Regulators of the Asexual Life Cycle of Aspergillus nidulans

Cells, 2023
The genus Aspergillus, one of the most abundant airborne fungi, is classified into hundreds of species that affect humans, animals, and plants. Among these, Aspergillus nidulans, as a key model organism, has been extensively studied to understand the ...
Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park
doaj   +1 more source

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. [PDF]

PLoS Biology, 2011
While multiple studies have reported the accelerated evolution of brain gene expression in the human lineage, the mechanisms underlying such changes are unknown. Here, we address this issue from a developmental perspective, by analyzing mRNA and microRNA
Mehmet Somel, Xiling Liu, Lin Tang, Zheng Yan, Haiyang Hu, Song Guo, Xi Jiang, Xiaoyu Zhang, Guohua Xu, Gangcai Xie, Na Li, Yuhui Hu, Wei Chen, Svante Pääbo, Philipp Khaitovich   +14 more
doaj   +1 more source

The engineering of developmental regulation [PDF]

Developmental Biology, 2008
It is fast becoming clear that, to understand the complexity of biological systems, it is not enough just to have mechanistic explanations for how things happen. We also need explanations for why things are there, i.e. what it is about particular states of affairs that enabled them to have been selected for.
openaire   +3 more sources

Different Preclimacteric Events in Apple Cultivars with Modified Ripening Physiology

Frontiers in Plant Science, 2017
“Anna” is an early season apple cultivar exhibiting a fast softening and juiciness loss during storage, in comparison to two mid-late season cultivars “Galaxy” and “GD.” The poor storage capacity of “Anna” was correlated with high lipid oxidation-related
Vikram Singh, Asya Weksler, Haya Friedman   +2 more
doaj   +1 more source