Results 201 to 210 of about 334,033 (329)

Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators

, 2005
Dolf Weijers, Eva Benková, Katja E. Jäger, Alexandra Schlereth, Thorsten Hamann, Marika Kientz, Jill C. Wilmoth, Jason W. Reed, Gerd Jürgens   +8 more
openalex   +2 more sources

fus/TLS orchestrates splicing of developmental regulators during gastrulation [PDF]

, 2012
Darwin S. Dichmann, Richard M. Harland
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

, 2006
Tong Ihn Lee, Richard G. Jenner, Laurie A. Boyer, Matthew G. Guenther, Stuart S. Levine, Roshan Kumar, B. Chevalier, Sarah E. Johnstone, Megan F. Cole, Kyoichi Isono, Haruhiko Koseki, Takuya Fuchikami, Kuniya Abe, Heather L. Murray, Jacob Zucker, Bingbing Yuan, George W. Bell, Elizabeth Herbolsheimer, Nancy M. Hannett, Kaiming Sun, Duncan T. Odom, Arie P. Otte, Thomas L. Volkert, David P. Bartel, Douglas A. Melton, David K. Gifford, Rudolf Jaenisch, Richard A. Young   +27 more
openalex   +1 more source

Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain [PDF]

, 2013
Paul R. Evans, Sarah E. Lee, Yoland Smith, John R. Hepler   +3 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP transcription factor FlbB. [PDF]

Cell Mol Life Sci, 2019
Otamendi A, Perez-de-Nanclares-Arregi E, Oiartzabal-Arano E, Cortese MS, Espeso EA, Etxebeste O.   +5 more
europepmc   +1 more source

1P217 Structural and functional characterization of BldD, an essential developmental regulator of Streptomyces coelicolor(7. Nucleic acid binding protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Changjin Lee, Jeong‐Mok Kim, In‐Kwon Kim, Sa-Ouk Kang   +3 more
openalex   +2 more sources

Characterization of P lasmodium developmental transcriptomes in A nopheles gambiae midgut reveals novel regulators of malaria transmission [PDF]

, 2014
Karolina A. Akinosoglou, Ellen Bushell, Chiamaka Valerie Ukegbu, Timm Schlegelmilch, Jee‐Sun Cho, Seth Redmond, Katarzyna Sala, George K. Christophides, Dina Vlachou   +8 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source