Results 241 to 250 of about 357,386 (324)

Senescence-Associated Sugar Transporter1 affects developmental master regulators and controls senescence in Arabidopsis [PDF]

Jintao Cheng, Meerim Arystanbek Kyzy, A. Heide, Azkia Khan, Martin Lehmann, Laura Schröder, Thomas Nägele, Benjamin Pommerrenig, Isabel Keller, H. Ekkehard Neuhaus   +9 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Developmental regulatory genes in recalcitrant forest trees: advances in somatic regeneration and genetic transformation. [PDF]

Front Plant Sci
Wang Y, Wang JH, Guo PR, Peng J, Xie CZ, Shi YD, Wu YH, Liao DZ, Sheng S.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration [PDF]

Aiko Kawasumi, Sang‐Woo Lee, Daisuke Ohtsuka, K Niimi, Yoshifumi Asakura, Keiichi Kitajima, Yuto Sakane, Koji Tamura, Haruki Ochi, Kenichi Suzuki, Yoshihiro Morishita   +10 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Promoter Motif Profiling and Binding Site Distribution Analysis of Transcription Factors Predict Auto- and Cross-Regulatory Mechanisms in <i>Arabidopsis</i> Flowering Genes. [PDF]

Int J Mol Sci
Virág E, Tóth BB, Kutasy B, Nagy Á, Pákozdi K, Pallos JP, Kardos G, Hegedűs G.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Transcriptional networks shaping malting quality in barley: From grain development to brewing performance. [PDF]

Food Chem (Oxf)
Panahi B, Hamid R, Ghorbanzadeh Z, Golkari S, Yildirim M, Jacob F.   +5 more
europepmc   +1 more source