Results 41 to 50 of about 357,386 (324)

Cell-fate transition and determination analysis of mouse male germ cells throughout development

open access: yesNature Communications, 2021
The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome landscapes of mouse male germ cells throughout development and find several critical regulators for ...
Jiexiang Zhao   +20 more
doaj   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

open access: yes, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing   +8 more
core  

Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]

open access: yes, 2008
Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D.   +3 more
core   +1 more source

Review and Validation of Plant Gene Function Research Methods Bypassing Tissue Culture

open access: yesAgronomy
The genetic transformation of plants has provided fundamental insights into plant biology. However, the genetic transformation systems for most horticultural plants remain incomplete.
Huanghuang Jiang   +9 more
doaj   +1 more source

Development and regulation of chloride homeostasis in the central nervous system

open access: yesFrontiers in Cellular Neuroscience, 2015
GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter of the mature central nervous system. The developmental switch of GABAergic transmission from excitation to inhibition is induced by changes in Cl- gradients, which are generated by ...
Miho eWatanabe, Atsuo eFukuda
doaj   +1 more source

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism. [PDF]

open access: yes, 2015
Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness.
Ayuso, Miriam   +12 more
core   +4 more sources

Evolution of asexual and sexual reproduction in the aspergilli [PDF]

open access: yes, 2018
Aspergillus nidulans has long-been used as a model organism to gain insights into the genetic basis of asexual and sexual developmental processes both in other members of the genus Aspergillus, and filamentous fungi in general.
Chen, W.   +10 more
core   +2 more sources

Current Advancement and Future Prospects in Simplified Transformation-Based Plant Genome Editing

open access: yesPlants
Recent years have witnessed remarkable progress in plant biology, driven largely by the rapid evolution of CRISPR/Cas-based genome editing (GE) technologies.
Xueying Han   +3 more
doaj   +1 more source

High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.

open access: yesPLoS ONE, 2014
The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry.
Thomas J F Nieland   +7 more
doaj   +1 more source

Cellular clarity: a logistic regression approach to identify root epidermal regulators of iron deficiency response

open access: yesBMC Genomics, 2023
Background Plants respond to stress through highly tuned regulatory networks. While prior works identified master regulators of iron deficiency responses in A.
Selene R. Schmittling   +4 more
doaj   +1 more source

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