Results 41 to 50 of about 165,041 (290)

Spatial Regulation of Developmental Signaling by a Serpin [PDF]

Developmental Cell, 2003
An extracellular serine protease cascade generates the ligand that activates the Toll signaling pathway to establish dorsoventral polarity in the Drosophila embryo. We show here that this cascade is regulated by a serpin-type serine protease inhibitor, which plays an essential role in confining Toll signaling to the ventral side of the embryo.
Jingjing W Miller, Carl Hashimoto, Dong Ryoung Kim, Donald Morisato, Linnea A. Weiss   +4 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Metabolic and Transcriptional Reprogramming in Developing Soybean (Glycine max) Embryos

Metabolites, 2013
Soybean (Glycine max) seeds are an important source of seed storage compounds, including protein, oil, and sugar used for food, feed, chemical, and biofuel production.
Ruth Grene, Lenwood S. Heath, Elijah Myers, Farzaneh Tabataba, Akshay Kakumanu, Curtis Klumas, Delasa Aghamirzaie, Yihui Fang, Eva Collakova   +8 more
doaj   +1 more source

Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes [PDF]

Developmental Cell, 2010
Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results in hemorrhage and edema. VEGF-C and
Ruben Böhmer, Martin Stehling, Friedemann Kiefer, Dayong Zhang, Brit Neuhaus, Sebastian Bühren, Barbara Böck   +6 more
openaire   +3 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology

Frontiers in Cell and Developmental Biology, 2021
The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell ...
Logan Meurer, Leonard Ferdman, Beau Belcher, Troy Camarata   +3 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Transduction of Signals during Somatic Embryogenesis

Plants, 2022
Somatic embryogenesis (SE) is an in vitro biological process in which bipolar structures (somatic embryos) can be induced to form from somatic cells and regenerate into whole plants.
Mohamed Elhiti, Claudio Stasolla
doaj   +1 more source

PRMT5-mediated regulation of developmental myelination [PDF]

Nature Communications, 2018
AbstractOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histone arginine methyl-transferase PRMT5, a molecule catalyzing symmetric methylation of histone H4R3,
Ting Zhou, Angeliki Mela, Julia Patzig, Julia Patzig, Jabez Bok, Patrizia Casaccia, Camila Yattah, Peter Canoll, Antonella Scaglione, Ernesto Guccione, Ernesto Guccione, Rebecca Frawley, Jialiang Liang, Shuibing Chen, Shun Xie Teo, Jingxian Zhang, Emily Bernstein   +16 more
openaire   +4 more sources