Results 51 to 60 of about 334,033 (329)
Developmental Regulation of dUTPase in Drosophila melanogaster [PDF]
Journal of Biological Chemistry, 2004 dUTPase prevents uracil incorporation into DNA by strict regulation of the cellular dUTP:dTTP ratio. Lack of the enzyme initiates thymineless cell death, prompting studies on enzyme regulation. We investigated expression pattern and localization of Drosophila dUTPase.
Katalin F. Medzihradszky +9 more
openaire +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Negative regulation and developmental competence in Aspergillus [PDF]
Scientific Reports, 2016 AbstractAsexual development (conidiation) in the filamentous fungusAspergillus nidulansis governed by orchestrated gene expression. The three key negative regulators of conidiation SfgA, VosA, and NsdD act at different control point in the developmental genetic cascade.
Jae-Hyuk Yu +5 more
openaire +2 more sources
Differentiation Requires Continuous Regulation [PDF]
, 1991 An abstract for this item is not ...
Baltimore, David, Blau, Helen M.
core +1 more source
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development. [PDF]
PLoS Genetics, 2015 While many transcriptional regulators of pluripotent and terminally differentiated states have been identified, regulation of intermediate progenitor states is less well understood.
Travis Walton +5 more
doaj +1 more source
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
Frontiers in Cell and Developmental Biology, 2021 The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell ...
Logan Meurer +3 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Spatial Regulation of Developmental Signaling by a Serpin [PDF]
Developmental Cell, 2003 An extracellular serine protease cascade generates the ligand that activates the Toll signaling pathway to establish dorsoventral polarity in the Drosophila embryo. We show here that this cascade is regulated by a serpin-type serine protease inhibitor, which plays an essential role in confining Toll signaling to the ventral side of the embryo.
Jingjing W Miller +4 more
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes [PDF]
Developmental Cell, 2010 Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results in hemorrhage and edema. VEGF-C and
Ruben Böhmer +6 more
openaire +3 more sources