Results 81 to 90 of about 165,041 (290)

A single-cell and tissue-scale analysis suite resolves Mixl1’s role in heart development

iScience
Summary: Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development. However, large-scale studies dissecting the molecular role of development master regulators in every cell type ...
Magdalena E. Strauss, Mai-Linh Nu Ton, Samantha Mason, Jaana Bagri, Luke T.G. Harland, Ivan Imaz-Rosshandler, Nicola K. Wilson, Jennifer Nichols, Richard C.V. Tyser, Berthold Göttgens, John C. Marioni, Carolina Guibentif   +11 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Developmental regulators moonlighting as transposons defense factors. [PDF]

Andrology, 2023
Tan K, Wilkinson MF.
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Optimised Agrobacterium-Mediated Transformation and Application of Developmental Regulators Improve Regeneration Efficiency in Melons. [PDF]

Genes (Basel), 2023
Wan L, Wang Z, Zhang X, Zeng H, Ren J, Zhang N, Sun Y, Mi T.   +7 more
europepmc   +1 more source

The Bacillus subtilis sin gene, a regulator of alternate developmental processes, codes for a DNA-binding protein [PDF]

, 1991
Nand K. Gaur, Joel D. Oppenheim, Issar Smith   +2 more
openalex   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome

Nature Communications, 2019
Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human ...
Wenliang Zhu, Boya Zhang, Mengqi Li, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou, Wei Li, Baoyang Hu   +9 more
doaj   +1 more source

polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. [PDF]

, 1993
Marie‐Odile Fauvarque, Jean‐Maurice Dura   +1 more
openalex   +1 more source