Results 101 to 110 of about 16,259 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Revista de Economia ContemporâneaRESUMO O artigo analisa a política industrial como instituição desenvolvimentista necessária ao desenvolvimento de economias retardatárias, contrastando os casos brasileiro e sul-coreano. Apesar das singularidades das economias analisadas, destaca-se que
Adriano José Pereira, Ricardo Dathein
doaj +1 more source
Maddening pre-service early childhood education and care through poetics: Dismantling epistemic injustice through mad autobiographical poetics. [PDF]
Contemp Issues Early Child, 2023 Davies AW.
europepmc +1 more source
From old to new developmentalism in latin America [PDF]
The failure of the Washington Consensus and of macroeconomic policies based onhigh interest rates and non-competitive exchange rates to generate economic growthprompted Latin America to formulate national development strategies. Newdevelopmentalism is an
Pereira, Luiz Carlos Bresser
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
From the national-bourgeois to the associated dependency interpretation of latin America [PDF]
In the 1960s and 1970s Latin America was the setting of modernizing militarycoups and of the transition of their intellectuals from nationalism to associated dependency.In the 1950s two groups of public intellectuals, organized around ECLAC, in Santiago,
Pereira, Luiz Carlos Bresser
core
Howard Gardner: the myth of multiple intelligences [PDF]
, 2004 This evening I want to examine Howard Gardner’s idea that there are multiple intelligences (MI theory). MI theory identifies some eight or nine types of intelligence: not only the logico-mathematical and linguistic kinds measured by ...
White, John
core +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The Knowledge of the Securitate: Secret Agents as Anthropologists
Studia Universitatis Babes-Bolyai Sociologia, 2017 In this paper I regard the Securitate (the Romanian secret police) as an epistemic form through which the socialist state gathered knowledge about reality, while it also performatively sought to create reality in keeping with its ideological ...
Poenaru Florin
doaj +1 more source