Results 161 to 170 of about 65,889 (299)

Atypical Change Detection in Sound Sequences: A Behavioral and Magnetoencephalography Study in Congenital Amusia. [PDF]

Eur J Neurosci
Lévêque Y, Fakche C, Fornoni L, Lecaignard F, Daligault S, Delpuech C, Jung J, Tillmann B, Caclin A.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Collective Deviance in IS

, 2018
Scholars in social psychology and criminology have long argued that deviance is a group phenomenon. Based on the collective deviance literature, we aim to investigate the mechanisms behind deviant behaviors among people in groups, uncovering reasons for ...
Mallmann, Gabriela Labres, Eckhardt, Andreas, Gastaud Maçada, Antônio Carlos   +2 more
core  

Dissociation in cross-feature integration between behavioral and pupil dilation responses in auditory deviant detection. [PDF]

iScience
Fatemi N, Liao HI, Elhilali M.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Positive deviance: A classificatory model

, 1998
The topic of positive deviance is analyzed in relation to how various theorists have conceptualized this particular type of deviance. In addition, the divergent examples of positive deviance/deviants that have been cited in the literature are reviewed ...
Heckert, Druann Maria
core  

Examining the moderating role of work engagement in predicting deviant behaviour: a study of work culture and organisational injustice among police officers. [PDF]

BMC Psychol
Bin Bujang MA, Manap J, Kalaivanan S, Selamat MN, Khan Z, Kamaluddin MR.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Leveraging the Positive Deviance Approach to Drive Behavior Change in Noncommunicable Diseases: A Scoping Review. [PDF]

Public Health Chall
Bouaddi O, El Badisy I, Charaka H, Kirat HEL, Boucham M, Obtel M, Khattabi A, Hassouni K, Belyamani L, Khalis M.   +9 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source