Results 91 to 100 of about 12,781 (247)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
How Influential are Adverse Childhood Experiences (ACEs) on Youths?: Analyzing the Immediate and Lagged Effect of ACEs on Deviant Behaviors. [PDF]
J Child Adolesc Trauma, 2022 Garduno LS.
europepmc +1 more source
DEVIANT BEHAVIOR IN ADOLESCENTS
Adolescent problems and parents' views on them. Thoughts were given on how to return teenagers with deviant behavior to educational life, educate them in the spirit of spirituality, and how to work with them in such cases.
Berdiyeva, Muborak +1 more
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The Effect of Job Security on Deviant Behaviors in Diverse Employment Workplaces: From the Social Identity Perspective. [PDF]
Int J Environ Res Public Health, 2021 Qin C, Wu K, Liu X, Liu S, Lu W.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Scientific ReportsPrevious research has examined the impact of internal organizational stress on employee innovation behavior, but recent research has not thoroughly examined whether artificial intelligence can aid frontline workers in innovating beyond their workflow ...
Xiaoru Du, Chunzi Cai
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Frontiers in PsychologyIntroductionThe current study aimed to examine the moderated mediation between perceived social support, the deviant behavior of new street corner youth on campus (NSCYC), interpersonal needs (as a mediator), and meaning in life (as a moderator).MethodsA
Hong Chi +3 more
doaj +1 more source