Results 61 to 70 of about 4,799,661 (289)

Overcoming the Inflammatory Stage of Non-Healing Wounds: In Vitro Mechanism of Action of Negatively Charged Microspheres (NCMs)

open access: yesNanomaterials, 2020
Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay in the inflammatory phase, unlocking the healing ...
Edorta Santos-Vizcaino   +7 more
doaj   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

open access: yes
Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Implantable electrical device [PDF]

open access: yes, 1982
A fully implantable and self contained device is disclosed composed of a flexible electrode array for surrounding damaged nerves and a signal generator for driving the electrode array with periodic electrical impulses of nanoampere magnitude to induce ...
Jhabvala, M. D.
core   +1 more source

Optimizing The Spatial Content Caching Distribution for Device-to-Device Communications

open access: yes, 2016
We study the optimal geographic content placement problem for device-to-device (D2D) networks in which the content popularity follows the Zipf law. We consider a D2D caching model where the locations of the D2D users (caches) are modeled by a Poisson ...
Al-Shalash, Mazin   +2 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Pre-Silicon Accurate SPICE Modeling of Trench MOSFETs via Advanced TCAD Simulations and Dynamic Validation

open access: yesMicromachines
This work presents a novel and fully virtual flow for extracting the SPICE model of a power MOSFET, starting exclusively from TCAD simulations. Unlike traditional approaches that rely on experimental silicon data, our methodology enables designers to ...
Ammar Tariq   +7 more
doaj   +1 more source

Fatigue testing device [PDF]

open access: yes, 1973
Anti-buckling assembly prevents buckling of sheet metal fatigue specimen when axial compressive load is applied. It provides for cyclic heating and cooling of specimen during testing. Assembly permits tests at two locations on specimen.
Eichenbrenner, F. E., Imig, L. A.
core   +1 more source

Portable anti-theft device [PDF]

open access: yes, 2020
In this rapid-evolving era, theft and robbery cases related to electronic equipment and vehicles among Malaysians society are more serious and critical. Among the most common cases are related to laptop, car, motorcycle theft and more.
Azim, Akif Rusyaidi   +3 more
core  

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