Results 21 to 30 of about 822,513 (242)
Monolithic centrifugal microfluidic platform for bacteria capture and concentration, lysis, nucleic-acid amplification, and real-time detection [PDF]
, 2009 We report the design, fabrication, and characterization of a polymer centrifugal microfluidic system for the specific detection of bacterial pathogens.
Barry, Thomas +5 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Condensate-removal device for heat exchangers [PDF]
, 1973 Device comprises array of perforated tubes manifolded together and connected to a vacuum suction device. Vacuum applied to these tubes pulls mixture of condensate and effluent gas through perforations and along length of tubes to discharge device ...
Oconnor, E. W., Trusch, R. B.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Recurrent sepsis post-cardiac device removal [PDF]
QJM, 2014 ### Learning Point for Clinicians Pacemaker infections are treated by device extraction that may not be complete. Pacing lead remnants rarely cause persistent infection and are detected on imaging. Despite high procedural success, cardiac device related infective endocarditis should be considered after device extraction in patients presenting with ...
V, Sawhney +3 more
openaire +2 more sources
Braking mechanism is self actuating and bidirectional [PDF]
, 1966 Mechanism automatically applies a braking action on a moving item, in either direction of motion, immediately upon removal of the driving force and with no human operator involvement.
Pizzo, J.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Development of a Novel Device for the Perfusion Driven Decellularization of Skeletal Muscle [PDF]
, 2014 Decellularization of skeletal muscle is a process that removes cellular components of skeletal muscle tissue while leaving behind the intact extracellular matrix (ECM).
Kasukonis, Benjamin
core +2 more sources
Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer [PDF]
, 2014 Failed root canal treatment is best addressed primarily with the provision of repeat endodontic treatment with thorough irrigation under isolation. If a post is present in the root of the tooth it needs to be removed first.
Jintong Du +7 more
core +1 more source