Results 41 to 50 of about 25,823 (154)

GLP‐1–Based Therapy in Type 1 Diabetes: Balancing Efficacy, Safety, and Patient Selection

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To critically examine the evolving evidence on glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and the dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 receptor agonist tirzepatide as adjuncts to insulin therapy in type 1 diabetes (T1D), with particular emphasis on their benefit–risk balance in individuals with ...
Thales Rossatto, Ricardo de Andrade Oliveira, Andréia Machado Cardoso   +2 more
wiley   +1 more source

Structure Identification and Risk Assurance of Unknown Impurities in Pramipexole Oral Drug Formulation

Advances in Pharmacological and Pharmaceutical Sciences
Impurities compounds in any pharmaceutical product or drug substance are inevitable from a chemistry point of view. The quality and safety of a pharmaceutical product are also significantly affected by these impurities content; therefore, impurities need
Raymond R. Tjandrawinata, Antonius H. Cahyana, Ajeng O. Nugroho, Indra K. Adi, Joseph S. R. Talpaneni   +4 more
doaj   +1 more source

Wiskott–Aldrich Syndrome Protein Is Required for Glucocorticoid‐Dependent Eosinopoiesis and Eosinophil‐Rich Inflammation in Murine Models

Immunology, EarlyView.
WASP links GC‐dependent bone marrow eosinopoiesis to eosinophil‐rich allergic lung inflammation. GC‐responsive WASP+ stromal niche drives eosinopoiesis, generating eosinophilic lung inflammation and airway hyperresponsiveness. In WASP‐deficient allergic asthma, GC production and airway hyperresponsiveness are preserved, but GC‐driven bone marrow ...
Bruno Marques Vieira, Lucas Everton Simões, Pedro Xavier‐Elsas, Maria Ignez Capella Gaspar‐Elsas   +3 more
wiley   +1 more source

Identification and Treatment of Anorexia Nervosa in Women With Perimenopause

Journal of Midwifery &Women's Health, EarlyView.
Abstract Disordered eating is a common problem that midwives will encounter as frontline primary care providers. Anorexia nervosa (AN) is a form of disordered eating that results in chronic starvation state, creating significant risk of morbidity and mortality to the patient. AN is traditionally considered a disorder of adolescence and young adulthood;
Janell Senda, Sarah Carpenter, Mary Carter‐Orbke   +2 more
wiley   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

Obesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo, Tamayo Mateo, Henao Diana, Juan P. Polanco, Cortés David, Juan C. Alba, Giha Valeria, Camargo Camilo, Hernández Eder, Correa Ricardo, Nassar Ricardo, Cabandugama Peminda, Marcio L. Griebeler, Burguera Bartolome   +13 more
wiley   +1 more source

The Cervical Vertebral Bone Quality Score Is a Novel Reliable Index Reflecting the Condition of Paraspinal Muscles and Predicting Loss of Cervical Lordosis After Open‐Door Laminoplasty

Orthopaedic Surgery, Volume 17, Issue 5, Page 1406-1417, May 2025.
There is a close correlation between C‐VBQ scores and the cervical deep extensors, deep flexors, and overall paraspinal muscles relative cross‐sectional area (RCSA) and degree of fat infiltration (DFF). The C‐VBQ score is a comprehensive parameter reflecting the quality of cervical bone and paraspinal muscles.
Junhu Li, Xingxia Long, Linnan Wang, Qiujiang Li, Lei Wang, Yueming Song   +5 more
wiley   +1 more source

Osteoporosis and osteomalacia - clinical and diagnostic problems

Travmatologiâ i Ortopediâ Rossii, 2016
Aim: to define main clinical and diagnostical problems related to osteoporosis and osteomalacia. Literature data showed that not only osteoporosis but osteomalacia may be the reason for decreasing of mechanical properties of skeleton with risk of low ...
A. S. Avrunin
doaj   +1 more source

Hypergravity enhances the therapeutic effect of dexamethasone in allergic asthma and rhinitis animal model. [PDF]

PLoS ONE, 2018
We investigated whether the therapeutic effects of dexamethasone for allergic asthma and rhinitis were enhanced in mice when exposed to hypergravity. Forty mice were divided into 5 groups (n = 8/group): Control group received saline intraperitoneally (i ...
Tae Young Jang, Ah-Yeoun Jung, Soonjo Kwon, Young Hyo Kim   +3 more
doaj   +1 more source

Systemic Physiological Impact on Cervical Bone Quality Measurements: A Comparative Analysis of Cervical Vertebral Bone Quality Scores and Hounsfield Units

Orthopaedic Surgery, EarlyView.
This study enrolled 512 patients with cervical spondylotic myelopathy to compare the physiological impacts on C‐VBQ score and C‐HU. The correlations of bilirubin and glucose metabolism indicators with both indices were stronger at the C4/5 segment and in female patients, and the C‐VBQ score appeared to be more sensitive to physiological factors than C ...
Fangze Qi, Yaoyu Wang, Yuchen Zhang, Tianshu Feng, Lianlei Wang, Xinyu Liu   +5 more
wiley   +1 more source

Dental implant survival, success, and failure in older populations: Beyond chronological age to systemic and local risk profiles

Periodontology 2000, EarlyView.
Abstract Aim Assess the effect of chronological aging on dental implant outcomes by reviewing clinical evidence on implant survival, success, failure, and marginal bone loss in elderly populations. Methods An electronic literature search of PubMed/MEDLINE and the Cochrane Library identified human studies published from January 1990 to July 2025 ...
Liza Harutyunyan, Yvonne L. Hernandez‐Kapila   +1 more
wiley   +1 more source