Results 41 to 50 of about 496,062 (355)

Longer term follow-up of the randomized phase III trial SWOG S0777: bortezomib, lenalidomide and dexamethasone vs. lenalidomide and dexamethasone in patients (Pts) with previously untreated multiple myeloma without an intent for immediate autologous stem cell transplant (ASCT)

Blood Cancer Journal, 2020
SWOG S0777, a randomized phase III trial, compared bortezomib, lenalidomide and dexamethasone (VRd) with lenalidomide and dexamethasone (Rd). This updated analysis includes 460 patients evaluable for survival endpoints: 225 eligible and analyzable ...
Brian G. M. Durie, A. Hoering, R. Sexton, M. Abidi, J. Epstein, S. Vincent Rajkumar, A. Dispenzieri, S. Kahanic, M. Thakuri, F. Reu, Christopher M. Reynolds, R. Orlowski, B. Barlogie   +12 more
semanticscholar   +1 more source

Anti-Inflammatory Treatment of COVID-19 Pneumonia With Tofacitinib Alone or in Combination With Dexamethasone is Safe and Possibly Superior to Dexamethasone as a Single Agent in a Predominantly African American Cohort

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2021
Objective: To explore the survival benefit of tofacitinib in addition to dexamethasone in hospitalized patients treated for coronavirus disease 2019 (COVID-19)–related pneumonia.
Maroun E. Hayek, MD, Michael Mansour, MD, Harrison Ndetan, MPH, MD, PhD, Quentin Burkes, PharmD, Robert Corkern, MD, Ammar Dulli, MD, Reya Hayek, BS, Karim Parvez, MD, Satwinder Singh, MD   +8 more
doaj   +1 more source

Widening use of dexamethasone implant for the treatment of macular edema [PDF]

, 2017
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.
Avitabile T., Bonfiglio V., Fallico M., Fichera S., Longo A., Macchi I., Pizzo A., Rapisarda C., Reibaldi M., Russo A.   +9 more
core   +2 more sources

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma

New England Journal of Medicine, 2018
BACKGROUND The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma.
M. Dimopoulos, D. Dytfeld, S. Grosicki, P. Moreau, N. Takezako, M. Hori, X. Leleu, R. LeBlanc, Kenshi Suzuki, M. Raab, P. Richardson, Mihaela Popa Mckiver, Ying‐Ming Jou, S. Shelat, Michael D. Robbins, B. Rafferty, J. San-Miguel   +16 more
semanticscholar   +1 more source

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]

, 2009
The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky, Bolton, De Bosscher, De Bosscher, Dervan, Gigu  re, Heck, Hermoso, Hsu, K. A. Muzikar, Kielkopf, Lampson, Lee, Li, McKay, N. G. Nickols, P. B. Dervan, Pratt, Reichardt, Ren, Spencer, Stockwell, Trauger, Wang, White, Wu, Young   +26 more
core   +2 more sources

Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats

Journal of Advanced Pharmaceutical Technology & Research, 2015
To evaluate the efficacy of cardamom with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats. There were four groups of 6 rats each.
G M Nitasha Bhat, Nagendra Nayak, K Vinodraj, N Chandralekha, Paul Mathai, J Cherian   +5 more
doaj   +1 more source

Qualitative and Quantitative Analysis of Dexamethasone in Rheumatic Pain Herbal Medicine Using Thin-Layer Chromatography (TLC) – Densitometry

Journal of Fundamental and Applied Pharmaceutical Science, 2021
Chemical medicine is chemical substances that is used as the main ingredient of chemical drugs. This compound is usually added to herbal medicine preparation to strengthen the indication of the traditional medicine.Chemical medicine was prohibited from ...
Desy Ayu Irma Permatasari, Novita Kurniasri, Muladi Putra Mahardika   +2 more
doaj   +1 more source

Trial of Dexamethasone for Chronic Subdural Hematoma.

New England Journal of Medicine, 2020
BACKGROUND Chronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.
P. Hutchinson, E. Edlmann, D. Bulters, A. Zolnourian, P. Holton, N. Suttner, Kevin Agyemang, S. Thomson, I. Anderson, Y. Al-Tamimi, D. Henderson, P. Whitfield, Monica Gherle, P. Brennan, Annabel Allison, E. Thelin, S. Tarantino, B. Pantaleo, K. Caldwell, C. Davis-Wilkie, H. Mee, E. Warburton, G. Barton, A. Chari, H. Marcus, A. King, A. Belli, P. Myint, Ian Wilkinson, T. Santarius, C. Turner, S. Bond, A. Kolias   +32 more
semanticscholar   +1 more source

The Influence of Hyperactivity of the Hypothalamic-pituitary-adrenal Axis and Hyperglycemia on the 5-HT2A Receptor-mediated Wet-dog Shake Responses in Rats [PDF]

, 2007
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-
Amano, Manabu, Araki, Hiroaki, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Suemaru, Katsuya, Umeda, Yuichi, Yamaguchi, Takumi   +7 more
core   +1 more source

Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

Life, 2021
Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis.
Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Takashi Yoshioka, Masashi Okada, Chifumi Kitanaka   +8 more
doaj   +1 more source