Dexamethasone Therapy for Bacterial Meningitis: Better Never Than Late?
Canadian Journal of Infectious Diseases, 1994 A multicentre randomized controlled trial was conducted in children with bacterial meningitis using dexamethasone or placebo for four days within 24 h of starting antibiotics. Primary outcomes were hearing loss and neurological abnormalities at 12 months
Susan M King +6 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2010 Purpose. Study the complexation of dexamethasone in combinations of y-cyclodextrin (yCD) and 2-hydroxypropyl-y-cyclodextrin (HPyCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery ...
Phatsawee Jansook +4 more
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BMC CancerBackground Dexamethasone has been used extensively to prevent hypersensitivity reactions to paclitaxel. However, the optimal dose of dexamethasone is controversial, varying between 20 mg and 10 mg.
Nutthakarn Sa-ngiamphorn +2 more
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Effects of dexamethasone on intracochlear inflammation and residual hearing after cochleostomy: A comparison of administration routes. [PDF]
PLoS ONE, 2018 Preservation of residual hearing after cochlear implant is an important issue with regards to hearing performance. Various methods of steroid administration have been widely used in clinical practice to reduce inflammation and preserve residual hearing ...
Ah-Ra Lyu +5 more
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Host stress drives Salmonella recrudescence [PDF]
, 2016 Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood.
Bert, Wim +12 more
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Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents. [PDF]
PLoS ONE, 2011 Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown.Vietnamese adults and adolescents with tuberculous meningitis recruited to a randomised, double-blind, placebo ...
M Estée Török +11 more
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Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]
, 2009 The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky +26 more
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Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. [PDF]
PLoS ONE, 2015 BACKGROUND:Dexamethasone has been studied as an effective adjuvant to prolong the analgesia duration of local anesthetics in peripheral nerve block. However, the route of action for dexamethasone and its potential neurotoxicity are still unclear. METHODS:
Ke An, Nabil M Elkassabany, Jiabin Liu
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High-Dose Dexamethasone Versus Tocilizumab in Moderate to Severe COVID-19 Pneumonia: A Randomized Controlled Trial [PDF]
, 2021 Naveen Naik B +19 more
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