Results 111 to 120 of about 65,011 (307)

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi, Priya Atodaria, Edmund Appiah‐Kubi, Zainab Shah, Elpidio Marlon Garcia   +4 more
wiley   +1 more source

A Hypnotic Response to Dexmedetomidine, an α2 Agonist, Is Mediated in the Locus Coerüleus in Rats [PDF]

, 1992
Christiane Corréa-Sales, Bradford C. Rabin, Mervyn Maze   +2 more
openalex   +1 more source

Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies

Cell Proliferation, EarlyView.
Global landscape. ABSTRACT Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, and quality of life. Emerging evidence suggests that ferroptosis is a critical factor in OA pathogenesis.
Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingfan Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Ventilatory Effects of Dexmedetomidine, Atipamezole, and Isoflurane in Dogs [PDF]

, 1992
Doanh Nguyen, Imad H. Abdul-Rasool, Denham S. Ward, Janet Hsieh, David Kobayashi, Shanna Hadlock, Fred D. Singer, B. C. Bloor   +7 more
openalex   +1 more source

DEXMEDETOMIDINE ALTERS THIOPENTAL DOSE REQUIREMENT AND DISTRIBUTION PHARMACOKINETICS [PDF]

, 1991
A. Mappes, Michael Bührer, Rolf Lauber, D. R. Stanski, P. Maitre   +4 more
openalex   +1 more source

Changes in microcirculation variables in an acute endotoxaemic equine model

Equine Veterinary Journal, EarlyView.
Abstract Background Microcirculation is the essential link between macrocirculation and cellular metabolism. Objectives To test our hypotheses that microcirculation variables will show a heterogeneous flow pattern during experimental endotoxaemia, and that fluid therapy and noradrenaline (NA) infusion will normalise altered microcirculation variables ...
Philipp K. Sauter, Barbara Steblaj, Sabine B. R. Kästner, Franz J. Söbbeler, Julia K. Reiners, Annette P. N. Kutter, Alvaro J. Gutiérrez Bautitsta, Stephan Neudeck   +7 more
wiley   +1 more source

The Effect of Dexmedetomidine on the Acute Pain After Cardiothoracic Surgeries: A Systematic Review

Brazilian Journal of Cardiovascular Surgery
Introduction: Acute post-operative pain remains a troublesome complication of cardiothoracic surgeries. Several randomized controlled trials have examined the efficacy of dexmedetomidine as a single or as an adjuvant agent before, during and after ...
Valiollah Habibi, Farshad Hasanzadeh Kiabi, Hassan Sharifi   +2 more
doaj   +1 more source

Pregabalin contributes to increased recovery time from isoflurane anaesthesia for magnetic resonance imaging in horses

Equine Veterinary Journal, EarlyView.
Abstract Background Pregabalin reduces excitatory neurotransmitter release and is used for anxiolysis in humans, cats, and horses. The effects of pregabalin on equine recovery following isoflurane anaesthesia are unknown. Objectives To determine if pre‐anaesthetic oral pregabalin influences recovery time and/or quality from isoflurane anaesthesia in ...
Abigail Blanton, Kati G. Glass, Jeanette Bayer, Courtney Baetge, Ryota Watanabe, Sarah N. Sampson, Mauricio Lépiz, Kara Moreno, Keila K. Ida   +8 more
wiley   +1 more source

A Neonatal Nurse‐Controlled Model of Analgesia to Manage Post‐Operative Pain in the Surgical Neonate: A Pilot Randomised Controlled Trial

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To test the feasibility and acceptability of a newly developed model of neonatal nurse‐controlled analgesia to manage pain in the post‐operative infant. Design The study utilised a single‐centre two‐arm parallel, unblinded randomised controlled external pilot trial design.
Renee Muirhead, Kathryn Kynoch, Glenda Hawley, Emma Ballard, Pita Birch, P. A. Lewis   +5 more
wiley   +1 more source