Results 71 to 80 of about 51,358 (247)

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li   +4 more
wiley   +1 more source

Double Asymmetric Spin Echo EPI (dASE‐EPI) Enables fMRI of the Entire Rat Brain at 9.4 T

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Development and evaluation of a double asymmetric spin echo planar imaging (dASE‐EPI) sequence to balance sensitivity to blood oxygenation level‐dependent (BOLD) contrast with mitigation of susceptibility‐induced intravoxel spin dephasing in ultra high‐field rodent brain imaging.
Kyle A. Johnson   +2 more
wiley   +1 more source

Clinical Electroencephalography for Anesthesiologists [PDF]

open access: yes, 2017
The widely used electroencephalogram-based indices for depth-of-Anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics.
Brown, Emery Neal   +3 more
core   +1 more source

Efficacy and Safety of Dexmedetomidine‐Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh   +5 more
wiley   +1 more source

Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures

open access: yesTherapeutics and Clinical Risk Management, 2010
Mohanad Shukry, Jeffrey A MillerUniversity of Oklahoma Health Sciences Center, Department of Anesthesiology, Children’s Hospital of Oklahoma, Oklahoma City, OK, USAAbstract: Dexmedetomidine was introduced two decades ago as a sedative and ...
Mohanad Shukry, Jeffrey A Miller
doaj  

Intraoperative dexmedetomidine-induced polyuria from a loading dose: a case report

open access: yesJournal of International Medical Research, 2020
With extensive perioperative use of dexmedetomidine, there has been rising concern about its side effects, which are most commonly bradycardia and hypotension.
Zhang Chen   +4 more
doaj   +1 more source

The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Emergence delirium commonly occurs in pediatric patients after general anesthesia, causing distress and potential harm. Remimazolam, an ultra‐short‐acting benzodiazepine, has recently been introduced in pediatric anesthesia, but its preventive role against emergence delirium remains unclear.
Ji‐Na Kim   +2 more
wiley   +1 more source

Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans [PDF]

open access: yes, 2017
State-dependent activity of locus ceruleus (LC) neurons has long suggested a role for noradrenergic modulation of arousal. However, in vivo insights into noradrenergic arousal circuitry have been constrained by the fundamental inaccessibility of the ...
Akeju, Oluwaseun   +5 more
core   +1 more source

Impact of Priming Volume Reduction on Hematocrit Retention in Pediatric Cardiopulmonary Bypass: A Retrospective Analysis

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Retrograde autologous priming and venous antegrade priming replace the cardiopulmonary bypass circuit crystalloid with patient blood to mitigate hemodilution. However, their effectiveness in pediatric patients, particularly when analyzed as continuous variables, remains unclear.
Tokimitsu Hibino   +10 more
wiley   +1 more source

Retrospective Evaluation of the Epidemiology and Practice Variation of Dexmedetomidine Use in Invasively Ventilated Pediatric Intensive Care Admissions, 2007-2013 [PDF]

open access: yes, 2015
OBJECTIVES: The study assessed dexmedetomidine utilization and practice variation over time in ventilated pediatric intensive care unit (PICU) patients; and evaluated differences in hospital outcomes between high- and low-dexmedetomidine utilization ...
Benneyworth, Brian D.   +2 more
core   +1 more source

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