Results 171 to 180 of about 280,112 (279)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

The Influence of Synthesis Parameters on the Properties of Dextran-Based Hydrogels for Colon-Targeted Antitumor Drug Delivery Part I: Room Temperature Synthesis of Dextran/Inulin Hydrogels for Colon-Targeted Antitumor Drug Delivery. [PDF]

Gels
Erceg T, Radosavljević M, Miljić M, Cvetanović Kljakić A, Baloš S, Špoljarić KM, Ćorić I, Glavaš-Obrovac L, Torbica A.   +8 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Effect of ribonucleic acid perfusion on canine kidney and liver homograft survival. [PDF]

, 1968
Brettschneider, L, Daloze, PM, Groth, CG, Huguet, C, Porter, KA, Smith, GV, Starzl, TE   +6 more
core  

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies.

J Mater Chem B
Westbay JH, Bigley DP, Sappa S, Ayalon A, Aweidah H, Dignam LD, Martel JN, Beltran WA, Sahel JA, Byrne LC, DiLeo MV.   +10 more
europepmc   +1 more source

Integrating Optical Feedback Alignment and Fluidic Control for Multiphase Flow-Assisted In Situ 3D Printing. [PDF]

J Sep Sci
Ramirez-Alvarado G, Passmann K, Romero-Rendon A, Sun G.   +3 more
europepmc   +1 more source

Freeze drying of pharmaceutical excipients close to collapse temperature: Influence of the process conditions on process time and product quality [PDF]

, 2009
Antonello A. Barresi, Carullo A., Davide Fissore, Franks F., MacKenzie A.P., Milton N., Roberto Pisano, Sabrina Ghio   +7 more
core   +1 more source

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

Advanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez, David Azorín‐Soriano, Araceli Lérida‐Viso, Jessie García‐Fleitas, Paula M Soriano‐Teruel, Jennifer Soler Beatty, Paula Rodrigo‐Martínez, Pau Arroyo, Sara Rojas‐Vázquez, Isabel Fariñas, Félix Sancenón, Juan F. Blandez, Alba García‐Fernández, Ramón Martínez‐Máñez   +13 more
wiley   +1 more source

Schistosoma mansoni soluble egg antigen and its key proteins differentially affect dextran sodium sulphate-induced inflammatory bowel diseaseFIRST REVIEW ROUND - REVIEWERS' COMMENTSREVIEWERS COMMENTS. [PDF]

Mem Inst Oswaldo Cruz
Fan HW, Lam HYP.
europepmc   +1 more source