Results 201 to 210 of about 205,279 (257)

Unlocking the therapeutic potential of traditional Chinese medicine in Crohn's disease: from multi-target mechanisms to clinical promise. [PDF]

Front Immunol
Zhou M, Chen Y, Hu J, Guo X, Jin W.
europepmc   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

Advanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi, Sukyoung Han, Jinho Kim, Ji Hye Han, Eunsu Kim, Yeonjeong Heo, Minju Lee, Jooyoung Lee, Heerim You, Soyoun Lee, Su‐Hee Han, Ilrok Yoon, Sung Anjeon, Hyerim Kang, Seungyeon Ryu, Hyun‐Ji Park, Eunha Kim, Chul Hwan Bang, Ji Hyun Lee, Josephine M. Egan, Jung‐Woong Kim, Eun Kyung Lee, Wook Kim   +22 more
wiley   +1 more source

How Complex Dietary Fibers Can Be Used to Shape the Human Gut Microbiome Toward Reduced Inflammatory Potential: A Pilot Study. [PDF]

Molecules
Savo Sardaro ML, Kuthyar S, Dada O, Deivassagayame N, Tran M, Kern R, Koenig S, Seidman Y, Atallah M, Amato KR.   +9 more
europepmc   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Distinguishing Free Cytosolic and Vesicle-Confined Nanoparticle Motion by Fluorescence Correlation Spectroscopy. [PDF]

J Phys Chem B
Kwapiszewska K, Bubak G, Bielec K, Magiera A, Zgorzelska A, Hołyst R.   +5 more
europepmc   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex. [PDF]

J Biol Chem
Hart T, Duke A, Zhou Y, Soukas AA, Yerevanian AI.   +4 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Contrasting Cannabinoid Receptor 2 (CB2R)-Associated Responses in Two Different Cerebrovascular Endothelial Cell Lines in a Blood Brain Barrier Model in the Context of HIV. [PDF]

Cells
Delorme-Walker V, Au K, Lim WL, Sasaki T, Furihata T, Lima DS, Grubbs NC, Castaneda J, Kufareva I, Iudicello J, Milner R, Marcondes MCG.   +11 more
europepmc   +1 more source