Results 211 to 220 of about 205,279 (257)

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Supramolecular nanofiber stabilization of microdroplets enables ultra-sensitive virus infection analysis. [PDF]

Nat Commun
Uchida N, Yaguchi A, Kondo S, Muranishi K, Kawabata H, Umezawa H, Ishimoto N, Tajiri M, Akashi S, Seki T, Watanabe G, Yoshida A, Higuchi G, Fu J, Takenouchi T, Yoshino D, Hiramatsu H, Okumura M, Saio T, Noji H, Lee YH, Park SY, Muraoka T.   +22 more
europepmc   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation [PDF]

Advanced science
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Mohanty S, Aydogdu M, Kang S, Li X, Edirisinghe M.   +4 more
europepmc   +2 more sources

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

<i>Pseudostellaria heterophylla</i> Polysaccharide Increases Colonic Mucus Thickness and Bacterial-Epithelial Distance in HFD/STZ-Induced Diabetic Mice. [PDF]

Curr Issues Mol Biol
Kan Y, Liu Y, Zhao L, Jiang C, Lin W, Pang W, Hu J.   +6 more
europepmc   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Supramolecular Assembly of an Antimicrobial Peptide Into a Pore

Angewandte Chemie, EarlyView.
Supramolecular assembly of an AMP is linked to transport across the Staphylococcus aureus membrane. ABSTRACT Antimicrobial peptides (AMPs) have long been ascribed the ability to form pores. These structures, some observed, others inferred, vary in their mechanisms of action, though most are associated with lysis.
Kathyana Deeyagahage, Poonam Dhindwal, Michal T. Boniecki, Antonio Ruzzini   +3 more
wiley   +2 more sources

RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse embryos. [PDF]

Sci Adv
Zhang XJ, Zhou CJ, Song CR, Feng ML, Xue FR, Sun D, Yang Q, Ding K, Jiang ZY, Liang CG.   +9 more
europepmc   +1 more source

Wetting‐Driven Transfer of Flexible Ultra‐Thin Temperature Sensors

Advanced Electronic Materials, EarlyView.
A wetting‐driven transfer approach enables ultra‐thin temperature sensors to be transferred from a super‐hydrophilic donor substrate onto rigid, curved, and biological receiver substrates. By combining controlled wetting with a conformal Parylene carrier layer, the method preserves stable thermal sensing performance while expanding the integration of ...
Hafiza Faiqa Maqsood, Annelot Nijkoops, Fahimeh Masoumi, Giuseppe Cantarella, Niko Münzenrieder, Riccardo Zamboni   +5 more
wiley   +1 more source

Soft Interactions, Rather Than Crowder Size, Determine Deviations From Arrhenius‐Like Kinetics of Phosphofructokinase‐1

Angewandte Chemie, EarlyView.
Our study investigates macromolecular crowding effects in the Arrhenius‐like and non‐Arrhenius temperature regimes of the human platelet isoform of phosphofructokinase‐1 (PFKP). The results reveal how PFKP maintains temperature robustness of catalytic activity in differently crowded environments.
Harshita Rastogi, Madhav Samanta, Truong‐An Nguyen, Mehrnoosh Khodam Hazrati, Bradley A. Webb, Eva Pluhařová, Stepan Timr, Simon Ebbinghaus   +7 more
wiley   +2 more sources