Results 31 to 40 of about 205,279 (257)

Investigation of urinary excretion of hydroxyethyl starch and dextran by UHPLC-HRMS in different acquisition modes [PDF]

, 2014
Plasma volume expanders (PVEs) such as hydroxyethyl starch (HES) and dextran are misused in sports because they can prevent dehydration and reduce haematocrit values to mask erythropoietin abuse.
K. Deventer, Deventer, Koen, L. Herregods, Van Eenoo, Peter, P. Van Eenoo, Roels, Kris, Herregods, Luc, S. Esposito, Verstraete, Alain, K. Roels, Jiménez Girón, Ana María, A.J. Giron, A. Verstraete, Esposito, Simone, Jimenez Giron, Ana   +14 more
core   +1 more source

SPIONs Prepared in Air through Improved Synthesis Methodology: The Influence of γ-Fe₂O₃/Fe₃O₄ Ratio and Coating Composition on Magnetic Properties

Nanomaterials, 2019
Superparamagnetic iron oxide nanoparticles (SPIONs) have shown great potential in biomedicine due to their high intrinsic magnetization behaviour. These are small particles of magnetite or maghemite, and when coated, their surface oxidation is prevented,
Joana C. Matos, M. Clara Gonçalves, Laura C. J. Pereira, Bruno J. C. Vieira, João Carlos Waerenborgh   +4 more
doaj   +1 more source

Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

, 2019
Biofilms are surface-attached bacterial communities embedded within an extracellular matrix that create localized and protected microenvironments. Acidogenic oral biofilms can demineralize the enamel-apatite on teeth, causing dental caries (tooth decay).
Aurea Simon-Soro, Sarah Gubara (6250523), David P. Cormode (1336467), Lizeng Gao, Yuan Liu, Venkata Jonnakuti (6250526), Yue Huang, Aurea Simon-Soro (6250529), David P. Cormode, Pratap C. Naha, Hyun Koo (133666), Yuan Liu (88411), Geelsu Hwang, Geelsu Hwang (472856), Dongyeop Kim (841369), Venkata Jonnakuti, Pratap C. Naha (6250520), Yue Huang (285485), Dongyeop Kim, Sarah Gubara, Hyun Koo, Lizeng Gao (406268)   +21 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice

, 2019
RNA interference (RNAi)-based gene therapy is a precision therapeutic approach for highly efficient sequence-specific gene silencing in vivo or in vitro. Caged RNAs featuring dextran conjugation of antisense and sense RNA strands using photolabile linker
Luzheng Xu (3407837), Changmai Chen (4925605), Luzheng Xu, Zhongyu Wang (171066), Zhongyu Wang, Xinjing Tang, Jinhao Zhang, Xinli Fan, Xinli Fan (6372812), Jinhao Zhang (6630860), Xinjing Tang (1444897), Changmai Chen   +11 more
core   +1 more source

Regioselective Bromination of the Dextran Nonreducing End Creates a Pathway to Dextran-Based Block Copolymers

, 2020
Preparation of polysaccharide-based block copolymers with linear architectures is an important goal, opening up clear application potential and requiring significant advances in polysaccharide regio- and chemoselectivity.
Laura Mosquera-Giraldo (8377953), Laura Mosquera-Giraldo, Glenn Spiering (8377950), Kevin J. Edgar (1495768), Glenn Spiering, Junyi Chen (776323), Robert B. Moore (1428184), Robert B. Moore, Junyi Chen, Kevin J. Edgar   +9 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review

Pharmaceuticals, 2018
Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs that are well described in the scientific literature.
Claire Desfrançois, Rachel Auzély, Isabelle Texier   +2 more
doaj   +1 more source

Dextran-Benzoporphyrin Derivative (BPD) Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Micelles for T₂‑Weighted Magnetic Resonance Imaging and Photodynamic Therapy

, 2019
Photodynamic therapy (PDT) has attracted extensive attention in recent years as a noninvasive and locally targeted cancer treatment approach. Nanoparticles have been used to improve the solubility and pharmacokinetics of the photosensitizers required for
Theresa M. Busch (322428), Ahmad Amirshaghaghi (5855252), Tianyan You (1465621), Andrew Tsourkas (221198), Cathy Meng (7840391), Lesan Yan (2879258), Zhiliang Cheng (1306029), Lijun Luo (161578), Joann Miller (322422)   +8 more
core   +1 more source