Results 181 to 190 of about 29,023 (291)

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Optimizing Drug Delivery to the Brain for Breast Metastasis: A Novel Method for Tumor Targeting. [PDF]

Cureus
Krishnamurthy S, Oh JY, Gautham S, Li J, Shen Y.   +4 more
europepmc   +1 more source

A comparison of Pluronic F-68, low molecular weight dextran, mannitol, and saline as priming agents in the heart-lung apparatus

, 1968
Alan C. Hymes, M.H. Safavian, Augustine Arbulu, Peter Baute   +3 more
openalex   +1 more source

Effect of DEAE-Dextran on Interferon Production and Protective Effect in Mice Treated with the Double-Stranded Polynucleotide Complex Polyinosinic-Polycytidylic Acid [PDF]

, 1969
F. Dianzani, G Rita, P Cantagalli, S. Gagnoni   +3 more
openalex   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Defining the Spatial Resolution of Analyte Recovery during Microperfusion-Based Sampling of Brain Parenchyma. [PDF]

ACS Chem Neurosci
Stangler LA, Chang SY, Kim I, Choi J, Kouzani AZ, Bennet KE, Burns TC, Van Gompel JJ, Worrell GA, Howe CL.   +9 more
europepmc   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source

Histidine containing dipeptides protect epithelial and endothelial cell barriers from methylglyoxal induced injury. [PDF]

Sci Rep
Wetzel C, Gallenstein N, Peters V, Fleming T, Marinovic I, Bodenschatz A, Du Z, Küper K, Dallanoce C, Aldini G, Schmoch T, Brenner T, Weigand MA, Zarogiannis SG, Schmitt CP, Bartosova M.   +15 more
europepmc   +1 more source

Recombination Between Guanidine-resistant and Dextran Sulfate-resistant Mutants of Type 1 Poliovirus [PDF]

, 1969
D Sergiescu, Andrei Aubert-Combiescu, R Crainic   +2 more
openalex   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source