Results 81 to 90 of about 18,616 (294)

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Effect of Various Infusion Solutions on Microrheology

Общая реаниматология, 2010
Objective: to evaluate the in vitro and in vivo effects of various infusion solutions on red blood cell rheology in the early posttraumatic period. Material and methods.
V. V. Moroz, L. V. Gerasimov, A. A. Isakova, Yu. V. Marchenkov, E.P. Rodionov   +4 more
doaj   +1 more source

FRAP in pharmaceutical research: practical guidelines and applications in drug delivery [PDF]

, 2013
Fluorescence recovery after photobleaching (FRAP) is a fluorescence microscopy technique that has attracted a lot of interest in pharmaceutical research during the last decades.
Braeckmans, Kevin, De Smedt, Stefaan, Demeester, Jo, Deschout, Hendrik, Raemdonck, Koen   +4 more
core   +2 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Pseudomonas aeruginosa Exoprotein-Induced Barrier Disruption Correlates With Elastase Activity and Marks Chronic Rhinosinusitis Severity

Frontiers in Cellular and Infection Microbiology, 2019
Background:Pseudomonas aeruginosa causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). P.
Jian Li, Jian Li, Jian Li, Mahnaz Ramezanpour, Stephanie A. Fong, Clare Cooksley, Jae Murphy, Masanobu Suzuki, Masanobu Suzuki, Alkis J. Psaltis, Peter John Wormald, Sarah Vreugde   +11 more
doaj   +1 more source

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale [PDF]

, 2009
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is however critical both for basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap,
A MacKenzie-Graham, A Reiner, A Vercelli, A Visel, Allan Jones, AM Hattox, Arthur W. Toga, AW Toga, AY Hardan, B Egaas, B Horwitz, BL Davidson, Brett D. Mensh, Bruce W. Stillman, C Gustafson, C Kobbert, Caizhi Wu, CL Veenman, Claus C. Hilgetag, Clifford B. Saper, CR Gerfen, D Atasoy, DA Benson, Daniel G. Herrera, David C. Van Essen, David Kleinfeld, DC Van Essen, DC Van Essen, DL Sparks, E Miyashita, ED Jarvis, Edward G. Jones, EM Callaway, ES Lein, ET Bullmore, F Castelli, F Crick, G Aston-Jones, H Markram, Hans C. Breiter, Harvey J. Karten, HC Breiter, Helen Barbas, Hemant Bokil, Henry A. Lester, Hollis T. Cline, IR Wickersham, J DeFalco, J Dejerine, J Panksepp, J Panksepp, Jaak Panksepp, James D. Watson, Jason W. Bohland, JD Schmahmann, Jeremy D. Schmahmann, JF Démonet, JG Bjaalie, JG Bjaalie, JG Bjaalie, JG White, JL Lanciego, JM Lin, John C. Doyle, John M. Lin, Joseph L. Price, Joseph Safdieh, K Oishi, K Wernicke, Karel Svoboda, KE Stephan, KE Stephan, L Ng, L Stein, Larry W. Swanson, LM Coolen, M Bota, M Bota, M Bota, M Murias, MA Just, MD Johnson, MI Ekstrand, Michael Hawrylycz, Mihail Bota, MJ Swift, N Geschwind, Nicholas D. Schiff, O Sporns, Olaf Sporns, Partha P. Mitra, Peter J. Freed, PH Luppi, PJ Broser, R Kotter, R Kotter, Ralph J. Greenspan, RH Güting, RM Kelly, Rolf Kötter, RW Baughman, S Folstein, S Lillehaug, S Mikula, Shawn Mikula, Suzanne N. Haber, U Burgel, U Frith, V Grinevich, Z. Josh Huang   +109 more
core   +9 more sources

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Dextrans in Aqueous Solution. Experimental Review on Intrinsic Viscosity Measurements and Temperature Effect [PDF]

, 2014
The study of biopolymers as dextran in aqueous solution, is effectively determined by intrinsic viscosity [η] measurements at different temperatures. Molecular weight (Mv) and hydrodynamic properties can be calculated from there.
Masuelli, Martin Alberto
core   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Bacterial Fluorescent-dextran Diffusion Assay

Bio-Protocol, 2014
Antimicrobial peptides are known to disrupt bacterial membranes allowing solutes to flow across the membrane in an unregulated manner resulting in death of the organism.
Neil O’Brien-Simpson, Namfon Pantarat, Katrina Walsh, Eric Reynolds, Marc-Antoine Sani, Frances Separovic   +5 more
doaj   +1 more source